Pyridazinone: an important element of pharmacophore …
2015年7月16日 · Pyridazinone, a derivative of pyridazine, was initially exploited in search of cardiovascular drugs and for its use in agrochemicals, but later on this nucleus was found to be associated with plethora of activities. In this article, we have reviewed the influence of structural changes on the pharmacodynamic profile of the pyridazinone moiety.
Anti-inflammatory activity of pyridazinones: A review
The pyridazinone core has emerged as a leading structure for fighting inflammation, with low ulcerogenic effects. Moreover, easy functionalization of various ring positions of the pyridazinone core structure makes it an attractive synthetic and therapeutic target for …
Pyridazinone - an overview | ScienceDirect Topics
Pyridazinone is a six-membered nitrogen-containing heterocyclic compound found in various therapeutic agents and is being explored for the development of new drug candidates targeting different diseases.
3(2H)-Pyridazinone | C4H4N2O | CID 68153 - PubChem
3(2H)-Pyridazinone | C4H4N2O | CID 68153 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The therapeutic journey of pyridazinone - ScienceDirect
2016年11月10日 · Pyridazinone causes direct relaxation of arteriolar smooth muscle by reducing arterial tone without affecting autonomic nervous system. The molecular mechanisms mediating this action are not clear, but may ultimately involve a fall in intracellular calcium concentrations.
Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent …
Our studies define pyridazinones as a drug scaffold with a well characterized mechanism of action distinct from those of existing antimalarial chemotherapies. PSAC and the pyridazinone derivatives have several properties that are ideal for development as part of a combination therapy regimen for malaria cure.
The therapeutic journey of pyridazinone - PubMed
2016年11月10日 · In this review, we have compiled and discussed various biological and therapeutic potential of pyridazinone derivatives. Keywords: Anti-inflammatory and analgesic; Anticancer; Antiviral; Biological activity; Heterocyclic; Pyridazinone.
Pyridazinone: an attractive lead for anti-inflammatory and
Pyridazin-3 (2H)-ones are nitrogen-rich heterocyclic compounds of considerable medicinal interest due to their diverse biological activities. The current review article focuses on progressive development of this attractive scaffold for the design and synthesis of new pyridazinone-based anti-inflammatory and analgesic agents.
Pyridazinone derivatives as potential anti-inflammatory agents ...
2021年4月4日 · Based on this preliminary data, we describe herein the synthesis of new pyridazinone derivatives bearing an indole moiety in position 4 (structure in Scheme 1), their evaluation as potential PDE4B-inhibitors and their anti-inflammatory potential by regulating cytokine and chemokine production by macrophages.
Pyridazinones and Structurally Related Derivatives with Anti ...
2022年6月10日 · In an effort to identify novel anti-inflammatory compounds, we screened a library of pyridazinones and structurally related derivatives that were used previously to identify N-formyl peptide receptor (FPR) agonists.