Biologic and molecular effects of granulocyte colony-stimulating factor ...
2008年2月15日 · Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion.
Granulocyte colony-stimulating factor - Wikipedia
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
The efficacy and safety of the prophylactic application of PEG-rhG-CSF ...
2024年11月14日 · Pegylated recombinant human granulocyte-colony stimulating factor (PEG-rhG-CSF) is a long-acting regulatory factor generated through structural optimization of rhG-CSF. Compared with rhG-CSF, it has a long half-life and can continuously act on bone marrow haematopoietic cells.
Effects of long-acting versus short-acting granulocyte colony ...
6 天之前 · PEG-rhG-CSF, a long-acting G-CSF, significantly reduces the incidences of FN, all grades of myelosuppression, and grade 3/4 myelosuppression in chemotherapy patients with gynecologic malignancies after pelvic radiotherapy. The adverse events, including bone pain and skin rash, were mild.
Efficacy and safety of PEG-rhG-CSF versus rhG-CSF in preventing ...
2023年7月26日 · PEG-rhG-CSF has better efficacy and equal tolerance compared with rhG-CSF in preventing CIN in EBC patients receiving EC regimen. Moreover, a half-dose 3 mg PEG-rhG-CSF also had good efficacy.
Effect of Recombinant Human Granulocyte Colony ... - JAMA …
The blue curve indicates the recombinant human granulocyte colony-stimulating factor (rhG-CSF) group, whereas the orange curve denotes the control group (usual care). The hazard ratio (HR) of achieving clinical improvement, along with the 95% CI and the P value, is also reported.
Clinical Applications of Recombinant Human Granulocyte …
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is primarily indicated for neutropenia caused by various etiologies in clinical practice. Recently, it has been shown to have some therapeutic effects and be safe for mother and child in some clinical research and treatment of reproductive diseases.
Effects of recombinant human granulocyte colony-stimulating …
The aim of the present review article is to examine the following aspects of rhG-CSF therapy: 1) does rhG-CSF influence neutrophil functions, and in particular their microbicidal properties? 2) does rhG-CSF modify neutrophil phenotype? 3) If so, …
Recombinant human granulocyte colony-stimulating factor …
2001年1月15日 · The purpose of this study was to evaluate the efficacy and toxicity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy in patients with neutropenia and/or neutrophil dysfunction secondary to glycogen storage disease (GSD) type 1b.
Human granulocyte colony stimulating factor (hG-CSF): cloning ...
2008年4月4日 · Human granulocyte colony stimulating factor (hG-CSF) is a hematopoietic cytokine that acts on cells of the neutrophil lineage causing proliferation and differentiation of committed precursor cells and activation of mature neutrophils.