Jurkat-Lucia™ NFAT Cells | NFAT Reporter T lymphocytes
Jurkat-Lucia™ NFAT cells are derived from the human T lymphocyte Jurkat cell line through the stable integration of an NFAT-inducible reporter gene encoding the Lucia luciferase. As a result, these cells allow the study of the nuclear factor of activated T cells (NFAT) pathway, by measuring the Lucia activity in the cell culture supernatant ...
NFAT-Luc Reporter Jurkat Cell Line 细胞系以Jurkat 为工具细胞，采用慢病毒感染的方 式，构建稳定表达NFAT-Luc 报告基因的细胞系，可用于检测NFAT 信号转导。在被促炎细 胞因子或受体兴奋剂激活后，内源性NFAT 转录因子与DNA 反应元件结合，诱导荧光素酶 报告基因的转录。
T Cell Activation Bioassay (NFAT) Technical Manual - Promega …
The assay consists of a genetically engineered Jurkat T cell line that expresses a luciferase reporter driven by an NFAT-response element (NFAT-RE). The TCR/CD3 Effector Cells (NFAT) are provided in Cell Propagation Model (CPM) format, which includes cryopreserved cells that can be thawed, propagated and banked for long-term use.
OncoWuXi速递 | Jurkat报告细胞赋能免疫治疗药物筛选 - 知乎
为助力新一代抗肿瘤药物研发，药明康德生物学业务平台肿瘤和免疫部团队在Jurkat细胞株上通过不同反应元件的插入和Jurkat 细胞表面抗原表达模式的工程化，构建了广泛的Jurkat 报告系统，可用于嵌合抗原受体（Chimeric antigen receptor, CAR）、T细胞受体（T cell receptor ...
ADCC检测Jurkat效应细胞株|Jurkat Cell Lines for ADCC Bioassays
YEASEN开发的Jurkat效应细胞株无菌、无支原体污染，细胞株为单克隆细胞株，可用于ADCC作用机制验证、糖基化水平检测、抗体筛选等应用。. 产品组分. 组分编号. 组分名称. 产品编号/规格. 42001ES03. 42001. Jurkat Cell Lines for ADCC Bioassays. 1mL（5E6 Cell/mL）.
Jurkat-Lucia™ NFAT cells were engineered from the human T lymphocyte Jurkat cell line. Jurkat cells naturally express a functional NFAT pathway3. Jurkat-Lucia™ NFAT cells stably express the Lucia luciferase reporter gene under the control of an ISG54 minimal promoter fused to six NFAT response elements. NFAT activation can
Jurkat-Lucia™ NFAT-CD32 cells | ADCP reporter | InvivoGen
InvivoGen offers Jurkat-Lucia™ NFAT-CD32 cells, specifically designed to assess the potency of specific immunoglobulin for ADCP (antibody dependent cell-mediated phagocytosis). A bioluminescent signal is produced by an NFAT-dependent Lucia luciferase reporter protein.
T Cell Activation Bioassay (NFAT/IL-2) - Promega Corporation
The T Cell Activation Bioassays consist of a genetically engineered Jurkat T cell line that expresses a luciferase reporter (TCR/CD3 Effector Cells) driven by either an NFAT-response element (NFAT-RE) or an IL-2 promoter.
The T Cell Activation Bioassay (NFAT)(a,b,c) (Cat.#. J1621, J1625), is a bioluminescent cell-based assay that overcomes the limitations of existing assays and can be used for the discovery and development of novel biologic and cell therapies aimed at inducing, strengthening and/or engineering T cell responses.
NFAT Reporter (Luc) – Jurkat Recombinant Cell Line - BPS …
The NFAT Luciferase Reporter Jurkat Cell Line expresses firefly luciferase under the control of the NFAT response elements stably integrated into the Jurkat cell genome. This reporter cell line is designed to monitor T cell activation as well as inhibition by various immune checkpoint inhibitors; it can be used as a control or parental cell ...