NaCl enhances CD8 + T cell effector functions in cancer ... - Nature
网页2024年8月28日 — Ki-67 + cells showed enhanced activation compared to their Ki-67 – counterpart, including increased expression of the HLA-DR activation marker, IRF4 and T-bet transcription factors and GZMB...
c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8 ...
网页2023年11月4日 — Cul4b promotes CD8 + T cell mediated antiviral immunity. Cul4b deficiency resulted in a decrease of CD44 + CD8 + effector/memory T cells in steady-state, prompting us to explore whether Cul4b...
Dietary fructose-mediated adipocyte metabolism drives antitumor CD8
网页2023年12月5日 — Importantly, GLUT5 deficiency in adipocytes decreased the frequencies of tumor-infiltrating Ki-67 + and IFN-γ + CD8 + T cells from tumor-bearing mice fed a high-fructose diet (Figures 5F and 5G). These results suggest that dietary fructose initiates adipocyte-derived leptin production, boosting the antitumor function of CD8 + T cells.
Prevalence of proliferating CD8 - National Center for …
网页2021年6月6日 — The evaluation of more than 20 different compartments of normal lymphoid tissues revealed that the percentage of proliferating (ki67 +) CD8 + cells did commonly not exceed 3%. In inflammations, the percentage of Ki67 + CD8 + cells was more variable and higher compared to normal tissues.
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
网页2024年4月10日 — FOXO1 overexpression, but not TCF7 overexpression, also significantly reduced expression of the exhaustion markers PD-1 and TIM3 on tumour-infiltrating CD8 + CAR T cells, whereas Ki-67...
Novel application of Ki67 to quantify antigen-specific in vitro ...
网页2010年10月10日 — We proposed that measurement of intracellular expression of the nuclear protein, Ki67, could reliably assess specific T cell proliferation in vitro. Ki67 was expressed in CD4+ and CD8+ T cells that had undergone in vitro proliferation after 6-day culture of human whole blood or PBMC with antigens.
Prognostic role of proliferating CD8 - PubMed
网页Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67 + )CD8 + Tcells and an inverse impact in colorectal and renal cell cancer.
A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis …
网页2021年1月5日 — The method combines Ki67 and DNA staining with major histocompatibility complex (MHC)-peptide-multimer staining and an innovative gating strategy, allowing us to successfully differentiate between antigen-specific CD8 T cells in G0, in G1 and in S-G2/M phases of the cell cycle in the spleen and draining lymph nodes of mice after vaccination ...
To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 …
网页2021年4月8日 — The Ki-67/DNA dual staining, or T DS assay, provides a reliable approach by which human peripheral blood can be used to reflect the dynamics of human lymphocytes, rather than providing mere steady-state phenotypic snapshots.
《癌细胞》：科学家发现激活抗肿瘤CD8阳性T细胞的关键树突状 …
网页2023年7月17日 — 从间质中走出来的这部分CD8阳性T细胞以高表达Ki-67为特征，提示它们 有着较强的增殖能力，适合在肿瘤微环境中打持久战；而且进一步分析还显示，这些CD8阳性T细胞大多存在 干细胞样特征，标志是转录因子TCF1阳性，在被cDC1细胞呈递的抗原激活 …