The therapeutic journey of pyridazinone - ScienceDirect
2016年11月10日 · Pyridazinone causes direct relaxation of arteriolar smooth muscle by reducing arterial tone without affecting autonomic nervous system. The molecular mechanisms mediating this action are not clear, but may ultimately involve a fall in intracellular calcium concentrations.
Pyridazinone: an important element of pharmacophore …
2015年7月16日 · Pyridazinone, a derivative of pyridazine, was initially exploited in search of cardiovascular drugs and for its use in agrochemicals, but later on this nucleus was found to be associated with plethora of activities. In this article, we have reviewed the influence of structural changes on the pharmacodynamic profile of the pyridazinone moiety.
Pyridazinone - an overview | ScienceDirect Topics
Pyridazinone is a six-membered nitrogen-containing heterocyclic compound found in various therapeutic agents and is being explored for the development of new drug candidates targeting different diseases. You might find these chapters and articles relevant to this topic. S.M. Heilmann, J.K. Rasmussen, in Comprehensive Heterocyclic Chemistry, 1984.
Anti-inflammatory activity of pyridazinones: A review - PubMed
The pyridazinone core has emerged as a leading structure for fighting inflammation, with low ulcerogenic effects. Moreover, easy functionalization of various ring positions of the pyridazinone core structure makes it an attractive synthetic and therapeutic target for the design and synthesis of anti-inflammatory agents.
Pyridazinones and Structurally Related Derivatives with Anti ...
2022年6月10日 · In an effort to identify novel anti-inflammatory compounds, we screened a library of pyridazinones and structurally related derivatives that were used previously to identify N-formyl peptide receptor (FPR) agonists.
Pyridazinones: A versatile scaffold in the development of …
Pyridazinones are important nitrogen‐rich heterocyclic core that has been driving the substantial medicinal interest due to their wide range of biological activities. This privileged scaffold forms a central core in numerous potent compounds, which results in the development of novel anticancer drugs with fruitful biological activities.
Ribosome-mediated biosynthesis of pyridazinone oligomers in …
2022年10月24日 · We surmised that coupling and rearrangement of activated hydrazines and γ-keto esters by the ribosome could produce 6-membered heterocyclic rings called pyridazinones (Fig. 1). Several features...
Pyridazin-3(2H)-ones: the versatile pharmacophore of medicinal ...
2012年10月9日 · Pyridazin-3(2H)-one derivatives have attracted the attention of medicinal chemists during the last decade due to their diverse pharmacological activities. Easy functionalization of various ring positions of pyridazinones makes them an attractive synthetic building block for designing and synthesis of new drugs.
Pyridazinones show a diverse range of agrochemical and pharmacological activities including cardiotonic, bron-chodilatory, anti-inflammatory, antiulcer, antidiabetic, and antiplatelet activity. Specially, the introduction of alkyl and aryl substituents on the 4-, 5-, and 6-positions may lead to
The therapeutic journey of pyridazinone - PubMed
2016年11月10日 · Pyridazinones have drawn a substantial attention within the field of research analysis and development. The moiety is a subject matter of intensive research because of its wide spectrum of biological activities and therapeutic applications. The synthesis of pyridazinone and investigation of their ch …