Pathology Outlines - Membranous nephropathy
2022年3月21日 · Which of the following findings favors primary membranous nephropathy over secondary forms? Glomerular basement membrane spikes by PAS and silver stains Intense global and granular PLA2R and IgG4 staining of glomerular basement membrane
AJKD Atlas of Renal Pathology: Membranous Nephropathy
In early MN, small deposits may be visualized as a pinpoint “hole” on Jones silver stain, which does not stain the deposits. Ongoing glomerular basement membrane matrix reaction to the deposits results in a “spike” appearance resulting from projections of basement membrane matrix out towards the urinary space on silver stain (stage II).
Membranous nephropathy (MN) is an immune complex disease caused by subepithelial deposits. Primary MN is a common cause of nephrotic syn-drome. About a third of patients reach remission, a third are stable, and a third have progressive loss of kidney function and persistent proteinuria.
Membranous Nephropathy - StatPearls - NCBI Bookshelf
2023年6月5日 · Membranous nephropathy (MN), also known as membranous glomerulopathy, is one of the many glomerular diseases causing nephrotic syndrome. It is characterized by proteinuria, presenting with peripheral edema and frothy urine. The etiology can be primary or secondary. A kidney biopsy is used to confirm the diagnosis of membranous nephropathy.
Renal Pathology - University of Utah
A silver stain of the glomerulus highlights the proteinaceous basement membranes in black. There are characteristic "spikes" of basement membrane between the immune deposits of membranous nephropathy. The black basement membrane material shown here appears as …
Kidney Biopsy of the Month: Membranous Nephropathy
2021年6月5日 · The deposits are light pink on the Jones silver stain and bright red on the trichrome stain (Figures 3, 4 & 5). Later on, lucencies may develop in GBMs as the immune deposits are resorbed. There is no conspicuous proliferation of resident glomerular cells or glomerular infiltration by inflammatory cells.
Membranous nephropathy: Clinical manifestations and diagnosis
2024年1月8日 · Membranous nephropathy (MN) is among the most common causes of the nephrotic syndrome in adults without diabetes, accounting for up to one-third of biopsy diagnoses in some regions.
Membranous nephropathy - PMC
Membranous nephropathy (MN) is a glomerulopathy defined by very characteristic morphological findings that include subepithelial immune deposits in the glomerular capillary loops. The clinical picture consists of nephrotic syndrome (NS) or asymptomatic proteinuria and, although it may occur in any age group, it is rare in children and ...
Renal Pathology - University of Utah
By electron microscopy in membranous nephropathy, the darker electron dense immune deposits are seen scattered within the thickened basement membrane. The "spikes" seen with the silver stain represent the intervening matrix of basement membrane between the deposits.
Membranous nephropathy: diagnosis, treatment, and …
2019年12月6日 · This newly formed matrix gives rise to the spikes characteristically seen on Jones’ silver stain, while the deposits which do not stain with silver produce a pattern of “craters” or “pits” when observed in a grazing section of the GBM.