Toll-like receptor 3 - Wikipedia
TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised by macrophages and dendritic cells.
Toll-like Receptors and the Control of Immunity - Cell Press
Kagan and Fitzgerald comprehensively review the functions and mechanisms of Toll-like receptors (TLRs), which are crucial detectors of microbial biomolecules and mediators of cellular immunity. They synthesize the overarching themes that have emerged from TLR signaling but are repeated throughout the pattern recognition receptor (PRR) superfamily.
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in …
2021年8月15日 · Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response.
Decoding Toll-like receptors: Recent insights and perspectives in ...
2024年4月9日 · Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs).
Toll Like Receptor 3 - an overview | ScienceDirect Topics
Toll-like receptor 3 (TLR3) is thought to be a major mediator of cellular response to viral infection, because it responds to double-stranded (ds) RNA, a common by-product of viral replication. This article is focused on the nature of the signaling pathways activated by TLR3 and dsRNA.
7098 - Gene ResultTLR3 toll like receptor 3 [ (human)]
Toll-like receptor 3 as a new marker to detect high risk early stage Non-Small-Cell Lung Cancer patients. Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility.
Toll Like Receptor 3 - an overview | ScienceDirect Topics
Toll-Like Receptor-3. Toll-like receptor-3 (TLR-3) is activated by dsRNA), a marker of viral infection, and, through the activation of NF-κB, triggers the production of type I interferons. TLR-3 is found on plasma membranes, where it is believed to contact dsRNA after the lysis of infected cells and release of dsRNA into the extracellular milieu.
Toll-like receptor (TLR) 3 immune modulation by unformulated …
The Toll-like receptors (TLRs) 3, 7, 8 and 9 stimulate innate immune responses upon recognizing pathogen-derived nucleic acids. TLR3 is located on the cell surface and in cellular endosomes and recognizes double-stranded viral RNA or the synthetic mimic poly rI:rC.
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in ...
2021年8月28日 · Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs) proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response.
Toll-Like Receptor 3 - an overview | ScienceDirect Topics
TLR3 is a pattern recognition receptor triggered by viral double-stranded RNA and leading to the activation of specific transcription factors, which stimulate the production of cytokines that induce a complex program of innate immune responses facilitating viral, including HSV, clearance.
Toll-like receptor 3 in viral pathogenesis: friend or foe?
2013年9月12日 · Toll-like receptor 3 (TLR3) participates in both defence and offence in host immunity to viruses. TLR3 recognizes dsRNA, a common intermediate of replication among many viruses.
Toll-like receptor - Wikipedia
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain
2005年7月22日 · Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs).
Engagement of Toll-Like Receptor 3 Induces Vascular Endothelial …
Keywords: Toll-like receptor 3; Arthritis, rheumatoid; Vascular endothelial growth factor; Interleukin-8; Synovial fibroblast. INTRODUCTION. Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by chronic inflammatory and destructive polyarthritis. The low oxygen tension of the RA synovial fluid is a potent stimulus for ...
Toll-Like Receptor 3 in Cardiovascular Diseases
Toll-like receptor 3 (TLR3) is an important member of the TLR family of innate immunoreactive receptors, and more and more studies have confirmed that TLR3 participates in the occurrence and development of cardiovascular diseases (CVDs) .
Toll-Like Receptor 3 in Cardiovascular Diseases - PubMed
An increasing number of studies have confirmed that TLR3, as a crucial medium of innate immunity, participates in the occurrence and development of cardiovascular diseases (CVDs) by regulating the transcription and translation of various cytokines, thus affecting the structure and physiological function of resident cells in the cardiovascular sy...
Roles of Toll-Like Receptor 3 in Human Tumors - PubMed
2021年4月27日 · Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons.
Toll-like receptor 3 in Epstein-Barr virus-associated …
Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Hacker G. Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells.
Toll-Like Receptor 3 in Cardiovascular Diseases - ScienceDirect
2022年7月1日 · Toll-like receptor 3 (TLR3) is an important member of the innate immune response receptor toll-like receptors (TLRs) family, which plays a vital role in regulating immune response, promoting the maturation and differentiation of immune cells, and participating in the response of pro-inflammatory factors.
Toll-like receptor 9 - Wikipedia
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. [5] TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natural killer cells, and other antigen presenting cells. [5]
Toll-like Receptor 3 (TLR3) Signaling Requires TLR4 Interactor with ...
2011年11月4日 · We have identified TRIL (TLR4 interactor with leucine-rich repeats) as a novel modulator of TLR4 signaling showing high expression in the brain. We now show that TRIL also plays a role in TLR3 signaling. TRIL is expressed intracellularly in the astrocytoma cell line U373 and in the monocytic cell line THP1.
Toll-like receptor 9 and 4 gene polymorphisms in ... - PubMed
2021年7月3日 · Toll like receptors (TLRs) are postulated to be involved in the innate immune responses to malaria. Individual studies showed inconclusive findings. This study aimed to assess the role of TLR4 (D299G, T399I) and TLR9 (T1237C, T1486C) in severity or susceptibility of malaria by meta-analysis of data from eligible studies.
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