Structure, function and dynamics in acyl carrier proteins - PMC
Acyl carrier proteins (ACPs) can be found as part of a multi-domain polypeptide (Type I ACPs), or as part of a multiprotein complex (Type II). Here, the main focus is on ACP2 and ACP3, domains from the type I trans -AT polyketide synthase MmpA, which is a core component of the biosynthetic pathway of the antibiotic mupirocin.
Acyl carrier protein - Wikipedia
The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. [1] In both cases, the growing chain is bound to the ACP via a thioester derived from the …
Acyl carrier protein: structure-function relationships in a
Acyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bact …
Comparative structure, dynamics and evolution of acyl-carrier proteins ...
2020年1月1日 · Here, we report the structure, dynamics, and evolution of acyl carrier proteins from three human pathogens: Borrelia burgdorferi, Brucella melitensis and Rickettsia prowazekii, which could facilitate the discovery of new inhibitors of ACP function in pathogenic bacteria.
Acyl carrier protein structural classification and normal mode …
All acyl carrier protein primary and tertiary structures were gathered into the ThYme database. They are classified into 16 families by amino acid sequence similarity, with members of the different families having sequences with statistically highly significant differences.
Acyl Carrier Protein in Fatty Acid Biosynthesis: Structure
2024年10月27日 · Acyl carrier proteins (ACPs) are essential in fatty acid biosynthesis, acting as carriers that facilitate the transfer of acyl groups throughout this biochemical process. Their significance lies in their ability to interact with various enzymes, ensuring the proper assembly and elongation of fatty acids, which are vital components of cellular ...
Structural modification of acyl carrier protein by butyryl group
2008年12月2日 · Acyl carrier protein (ACP) shuttles the acyl intermediates between individual pathway enzymes. In this study, we determined the solution structures of three different forms of ACP, apo-ACP, ACP, and butyryl-ACP under identical experimental conditions.
Acyl carrier protein: structure–function relationships in a …
2007年11月20日 · Acyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bacteria and plastids (type II FAS).
Probing the structure and function of acyl carrier proteins to …
2020年9月16日 · Acyl carrier proteins (ACPs) play a central role in biosynthesis by shuttling malonyl-based building blocks and polyketide intermediates to catalytic partners for chemical transformations.
Acyl carrier protein: structure-function relationships in a …
Acyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bacteria and plastids (type II FAS).