Amide ring - Wikipedia
Amide Rings are small motifs in proteins and polypeptides. They consist of 9-atom or 11-atom rings formed by two CO... HN hydrogen bonds between a side chain amide group and the main chain atoms of a short polypeptide. They are observed with glutamine or asparagine side chains within proteins and polypeptides.
21.7: Chemistry of Amides - Chemistry LibreTexts
Among the most important molecules that contain lactam rings are the penicillins: The amide functional group is extremely important for biological molecules because amides make up the backbone of proteins.
Amide Bond Activation of Biological Molecules - PMC
2018年10月12日 · One widely reported approach for the activation of amide bonds involves the distortion of amide bonds, thus, the amide bond is no longer able to form a resonating structure, loses its double bond character, and becomes more …
There are a number of functional groups structurally related to amides (and esters) that are important constituents of drug molecules and biomacromolecules. Perhaps the most important of these are the carbamates, ureas, imides and sulfonamides.
The Amide Functional Group: Properties, Synthesis, and Nomenclature
2018年2月28日 · What's an amide functional group? How are they made? What's the difference between a primary, secondary, and tertiary amide? All that and more, below.
β-Lactam - Wikipedia
A β-lactam (beta-lactam) ring is a four-membered lactam. [1] A lactam is a cyclic amide, and beta-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl.
21.7 Chemistry of Amides - Organic Chemistry - OpenStax
Amides undergo hydrolysis to yield carboxylic acids plus ammonia or an amine upon heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more extreme than those required for the hydrolysis of acid …
Nomenclature and properties of amides - Khan Academy
In terms of physical properties of amides, let's look at a little diagram here, showing acetamide. So we have our amide right here, and physical properties, in terms of what state of matter is this, acetamide is actually a solid, at room temperature and pressure, and so this is a solid.
Amide synthesis by acylation - Organic Chemistry Portal
LiNTf 2 is able to activate cyclic esters towards ring opening with a stoichiometric amount of amines, thus leading to clean open-chain amides under mild conditions. The generality of the method was demonstrated by a range of selected lactones and amines.
Amides - Chemistry LibreTexts
2023年1月23日 · A carboxylic acid contains the \(-COOH\) functional group, and in an amide the \(-OH\) part of that group is replaced by an \(-NH_2\) group. So, amides contain the \(-CONH_2\) group. The amide linkage has some interesting properties that may not be obvious from other chemical classes.