CD40 (protein) - Wikipedia
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
CD40 Gene - GeneCards | TNR5 Protein | TNR5 Antibody
Dec 9, 2024 · CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Agammaglobulinemia, X-Linked. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Targeting the CD40-CD40L pathway in autoimmune diseases: …
Feb 15, 2019 · This article will highlight what is known about the biology of the CD40-CD40L axis in humans and describe the potential contribution of CD40 signaling on both hematopoietic and non-hematopoietic cells to autoimmune disease pathogenesis.
CD40: Targeting Co-Stimulatory Pathways for Cancer …
Feb 7, 2019 · CD40 is constitutively expressed on APCs such as B cells and dendritic cells. It is also expressed on other hematopoietic cells including T cells and macrophages after cellular activation. CD40 expression can also be found on endothelial, CNS resident, and …
CD40 stimulation as a molecular adjuvant for cancer vaccines …
Jul 19, 2021 · In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma. Int. J. Hyperth. 2019;36:64–73.
Molecular basis and therapeutic implications of CD40/CD40L …
CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate.
What is CD40? - Mabtech
CD40, or cluster of differentiation 40, is a 48 kDa type I glycoprotein with a co-stimulatory function. It belongs to the tumor necrosis factor superfamily and binds to its ligand CD154 (CD40L).
CD40 is an immune checkpoint regulator that potentiates …
Mar 14, 2024 · Here, we leveraged genetic mouse models, single cell sequencing, and cell depletion studies to demonstrate that an anti-CD40 agonist antibody reshapes the cardiac immune landscape through activation of CCR2 + macrophages and subsequent recruitment of effector memory CD8 T-cells.
CD40/CD40L Signaling as a Promising Therapeutic Target for the ...
The cluster of differentiation 40 (CD40) is activated by the CD40 ligand (CD40L) in a variety of diverse cells types and regulates important processes associated with kidney disease. The CD40/CD40L signaling cascade has been comprehensively studied ...
CD40–CD40L in Neurological Disease - PMC - PubMed Central …
We have reviewed the role of CD40–CD40L in neurological diseases of non-infectious etiology and distinguished two general classes of CD40–CD40L therapies used to combat neurological disease: those that inhibit CD40–CD40L mediated neuroinflammation to attenuate the immune response and those that upregulate CD40 signaling for tumor cell lysis.