Cytokeratin 20 (CK20) - MyPathologyReport.ca
网页Cytokeratin 20 (CK20) is a protein made by epithelial cells in the colon and urinary tract. It is also made by Merkle cells in the skin. This type of protein is also made by most benign (noncancerous) and malignant (cancerous) tumours that start in the colon and urinary tract and in a type of skin cancer called Merkle cell carcinoma.
Keratin 20 - Wikipedia
网页Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. [5] [6] [7] Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. [8]
Cytokeratin 7 and cytokeratin 20 expression in cancer: A ... - PubMed
网页Combined analysis of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is often used for assessing the origin of metastatic cancer. To evaluate the diagnostic utility of CK7 and CK20, tissue microarrays containing 15,424 samples from 120 different tumor types and subtypes and 608 samples of 76 different ….
Identification of relevant prognostic values of cytokeratin 20 and ...
网页2017年12月12日 · Positive CK20 and CK7 expressions are detected in patients with lung cancer; positive expression of CK7 associated with pathological features of lymph node metastasis and T stage may be independent clinical parameters for poor prognosis of patients with lung cancer. Keywords: CK20, CK7, lung cancer, survival outcome.
Immunohistochemical staining of cytokeratin 20 and …
网页Relative expression of CK20/CK7 is an approved diagnostic tool to help determine site of origin in metastatic carcinomas. CK20 is specific for colonic, urothelial and Merckel cell carcinoma. On the other hand, CK7 is characteristic of glandular malignancies originating from breast, respiratory tract, biliary tract and Mullarian epithelium.
Cytokeratin 20 - an overview | ScienceDirect Topics
网页Cytokeratin 20 (CK20) is a type I acidic low molecular weight cytokeratin that is found in normal tissues of the stomach, intestine, urothelium, and in Merkel cells. It is also present in various types of adenocarcinomas, mucinous tumors of the ovary, and urothelial carcinoma.
Cytokeratin 20 - SpringerLink
网页2022年11月25日 · The CK20 is a type I simple keratin made of 424 amino acids and weighs 48 kDa. This keratin was first discovered by Moll and colleagues, who also described its pattern of expression in normal epithelia and tumors (Moll et al. 1992). It is usually associated with the basic type II cytokeratin 8 and is present in gastrointestinal epithelium ...
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon …
网页2016年1月21日 · The identification of high-risk stage II colon cancers is key to the selection of patients who require adjuvant treatment after surgery. Microarray-based multigene-expression signatures derived...
Cytokeratin 7 and Cytokeratin 20 Expression in Epithelial ... - Nature
网页2000年9月1日 · Cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) are low molecular weight cytokeratins. Their anatomic distribution is generally restricted to epithelia and their neoplasms.
The value of CDX2 and cytokeratins 7 and 20 expression in ...
网页2012年1月23日 · CK20 is expressed alone in the majority of intestinal adenocarcinoma and in Merkel cell carcinomas whereas CK7 is present without CK20 in most breast, lung and ovarian adenocarcinoma, and with CK20 in urothelial, pancreatic and gastric carcinomas.