Calmodulin - Wikipedia
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. [1] It is an intracellular target of the secondary messenger Ca 2+, and the binding of Ca 2+ is required for the activation of calmodulin.
Neuronal calmodulin levels are controlled by CAMTA …
2021年9月9日 · Using Caenorhabditis elegans and Drosophila, we show that CAMTAs control neuronal CaM levels. The behavioral and neuronal Ca 2+ signaling defects in mutants lacking camt-1, the sole C. elegans CAMTA, can be rescued by supplementing neuronal CaM. CAMT-1 binds multiple sites in the CaM promoter and deleting these sites phenocopies camt-1.
Calmodulin as a Direct Detector of Ca2+ Signals - PMC
where N x and C x represent binding sites on either the N or C lobe; after the first binding, the state changes from T to R, giving rise to cooperativity 11 (see Supplementary Fig. 2).The model had to correctly fit data that were measured over a wide range of experimental conditions. This strongly constrained the fits and assured that accurate kinetics were determined (see Methods).
Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of …
2021年3月3日 · Calmodulin (CaM) engages in Ca 2+ -dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction with the human Na + /H + -exchanger NHE1.
Calmodulin-controlled spatial decoding of oscillatory Ca
2014年7月23日 · Here, we use genetically encoded fluorescent biosensors to directly probe the role of cytosolic Ca 2+ oscillations in modulating calcineurin activity dynamics in insulin-secreting MIN6 β-cells.
Calmodulin enables intracellular fibroblast growth factor …
2024年2月8日 · Regulation of Nav1.5 inactivation is linked to multiple accessory proteins that bind its C-terminal domain (CTD) including calmodulin (CaM) and intracellular fibroblast growth factors (iFGF). Previous results demonstrate that Ca 2+-bound CaM preferentially binds to iFGF12A while apo-Ca 2+ can bind with the Nav1.5 CTD (Mahler et al. 2021). We ...
Calmodulin-controlled spatial decoding of oscillatory Ca2 ... - eLife
2014年7月23日 · Here, we use genetically encoded fluorescent biosensors to directly probe the role of cytosolic Ca 2+ oscillations in modulating calcineurin activity dynamics in insulin-secreting MIN6 β-cells.
Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of …
2021年3月3日 · Calmodulin (CaM) engages in Ca 2+-dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction with the human Na + /H +-exchanger NHE1. Using nuclear magnetic resonance (NMR) spectroscopy, isothermal titration calorimetry, and fibroblasts stably expressing wildtype and mutant NHE1 ...
determined by variations in the subcellular distribution of calmodulin (CaM), indicating that CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin signaling. Together, our findings provide new insights into the mechanisms by which oscillatory signals are
Calmodulin (CaM) is a major calcium signal trans-ducer and is involved in a variety of calcium-mediated cellular processes (19, 20). CaM was initially identified as an activator of brain phosphodiesterase (21). Sub-sequently, CaM was found in various organisms, in-cluding flagellated or ciliated organisms (22–24).
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