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    前往 Wikipedia 查看全部内容
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    Wikipedia
    https://en.wikipedia.org/wiki/CD22

    CD22 - Wikipedia

    CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of … 展开

    Structure

    CD22 is a transmembrane protein with a molecular weight of 140 kDa. The extracellular part of CD22 consists of seven 展开

    Autoimmunity 图像
    As a drug target

    Because CD22 is restricted to B cells, it is an excellent target for immunotherapy of B cell malignancies. There are several mechanisms by which this can be achieved, namely 展开

    概览 图像
    BCR signaling

    The intracellular 展开

    Autoimmunity

    Single-nucleotide polymorphisms in the CD22 gene lead to a higher likelihood of autoimmune disease. Specifically, some studies show that … 展开

    Interactions

    CD22 has been shown to interact with Grb2, PTPN6, LYN, SHC1 and INPP5D. 展开

    External links

    • CD22+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
    • Human CD22 genome location and CD22 gene details page in the UCSC Genome Browser.
    • Overview of … 展开

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    Structure
    BCR signaling
    Autoimmunity
    As a drug target
    Interactions
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  2. 知乎专栏
    https://zhuanlan.zhihu.com/p/575400163

    肿瘤免疫靶点 | CD22 - 知乎 - 知乎专栏

    网页本文介绍了CD22作为一种B细胞相关的肿瘤免疫靶点的特点和药物开发情况，包括已获批的ADC药物和CAR T疗法药物，以及中国抗体制药开发的SM03。文章还分析了CD22靶点的优势和挑战，以及未来的发展方向。

  3. 知乎专栏
    https://zhuanlan.zhihu.com/p/108467856

    CD22-B细胞受体辅因子 - 知乎 - 知乎专栏

    网页本文介绍了CD22是一种表达于B细胞和B细胞恶性肿瘤中的细胞表面粘附分子，可与唾液酸配体相互作用，调节B细胞的活性和发育。文章还介绍了CD22的亚型、结构、配体和信号通路，以及CD22在疾病中的作用和研 …

    标记:
    CD22
    抑制BCR

  4. CD22的图片

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  5. 每日生物评论
    http://www.bio-review.com/cd22

    CD22——自身免疫疾病和B细胞恶性肿瘤治疗的热门靶 …

    网页2020年12月22日 · 本文介绍了CD22是一种B细胞表面的抑制性辅助受体，与唾液酸结合，参与B细胞的发育和信号传导。文章还介绍了CD22作为免疫治疗的靶点，以及相关的抗体药物和CAR-T疗法的研究进展。

  6. 知乎专栏
    https://zhuanlan.zhihu.com/p/334659043

    快速了解CD20/CD22/CD38/CD80的生物学意义 - 知乎 - 知乎专栏

  7. 维基百科
    https://zh.wikipedia.org/zh-hans/CD22

    CD22 - 维基百科，自由的百科全书 - zh.wikipedia.org

  8. Nature
    https://www.nature.com/articles/s41467-017-00836-6

    Molecular basis of human CD22 function and therapeutic …

    标记:
    Cd22 B Cells
    Publish Year:2017
  9. PubMed
    https://pubmed.ncbi.nlm.nih.gov/30323814

    CD22: A Regulator of Innate and Adaptive B Cell Responses and ...

    标记:
    Cell Signaling Cd22 Antibody
    Cd22 B Cells
    CD22-regulated
    Cd22 Inhibitor
  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275043

    Targeting CD22 for the Treatment of B-Cell Malignancies

    标记:
    Cd22 B Cell
    Cell Signaling Cd22 Antibody
    Cd22 and Cancer
  11. GeneCards
    https://www.genecards.org/cgi-bin/carddisp.…

    CD22 Gene - GeneCards | CD22 Protein | CD22 Antibody

    网页2024年8月5日 · CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include Hematologic Cancer and Trichomoniasis. Among its related pathways are Antigen activates B Cell Receptor (BCR) …

    标记:
    Cd22 B Cell
    Cd22 and Cancer
    Cd22 Mediated Bcr Regulation