Cytochrome P450 3A inhibitors and inducers - UpToDate
For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation.
Rifamycins (rifampin, rifabutin, rifapentine) - UpToDate
2024年8月26日 · Rifamycins (most notably rifampin) are moderate to potent inducers of drugs undergoing metabolism by the cytochrome P450 enzyme system (notably CYP3A4), which can lead to reduced bioavailability and enhanced clearance of some coadministered medications.
Cytochrome P450 3A inhibitors and inducers - UpToDate
CYP: cytochrome P450. * Mifepristone is a significant inhibitor of CYP3A4 when used chronically (eg, for hyperglycemia in patients with Cushing syndrome), not in single-dose use. ¶ Classified as a weak inhibitor of CYP3A4, according to FDA system.
Inhibitors and inducers of P-glycoprotein drug efflux - UpToDate
Inducers of P-gp. Inhibitors of the P-gp drug efflux pump (also known as P-gp multidrug resistance transporter) listed above may increase serum concentrations of drugs that are substrates of P-gp, whereas inducers of P-gp drug efflux may decrease serum concentrations of substrates of P-gp. Examples of drugs that are substrates of P-gp efflux ...
Serotonin modulators: Pharmacology, administration, and side
2023年3月21日 · - Cytochrome P450 3A inhibitors and inducers - Cytochrome P450 2D6 (CYP2D6) inhibitors - Side effects of antidepressant medication - Serotonin syndrome agents - Pharmacology antidepressants - Serotonin modulator antidepressants: Pharmacokinetics; RELATED PATHWAYS. Unipolar major depression: Initial pharmacologic therapy in adults; …
Cytochrome P450 3A inhibitors and inducers - UpToDate
Moderate inducers. For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation.
Pharmacology of azoles - UpToDate
2023年1月25日 · The azoles that are available for systemic use can be classified into two groups: the triazoles (fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) and the imidazoles (ketoconazole). An overview of the use of azole agents for the treatment of various systemic fungal infections will be reviewed here.
Cytochrome P450 3A inhibitors and inducers - UpToDate
Cytochrome P450 3A inhibitors and inducers - UpToDate ... English ...
Drugs and the liver: Metabolism and mechanisms of injury
2024年7月30日 · - Cytochrome P450 3A inhibitors and inducers - Classification of toxic hepatocellular injury
Cyclosporine and tacrolimus nephrotoxicity - UpToDate
2024年1月4日 · Most data on CNI nephrotoxicity pertain to cyclosporine since it has been used for a much longer time. However, a similar pattern of kidney injury from cyclosporine is seen with the use of tacrolimus, thereby suggesting a drug class effect.