The therapeutic age of the neonatal Fc receptor - Nature
2023年2月1日 · Neonatal Fc receptor (FcRn) supports host defence through its role in antibody recycling and transcytosis, as well as by regulating immune effector cells together with classical Fc...
Neonatal fragment crystallizable receptor - Wikipedia
The neonatal fragment crystallizable (Fc) receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. [1] [2] [3] It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin.
靶向新生儿Fc受体：FcRn - 知乎 - 知乎专栏
FcRn的机构和功能. FcRn是一种位于细胞膜表面的IgG抗体受体，其蛋白结构和MHC-I分子类似（详见 抗体的FcR篇），主要在内皮细胞中表达（在其它组织或细胞中也能检测到），其结构包含由α链和β2微球蛋白组成的异二聚体（见下图）。 FcRn可以和IgG的Fc部分结合，阻止IgG分子被溶酶体裂解，可以起到增长IgG体内半衰期的作用，参与到IgG的体内转运、维持和分布代谢过程中。 FcRn的结构。 FcRn的结构包含由α链（α1、α2和α3）和β2微球蛋白组成的异二聚 …
FcRn: the neonatal Fc receptor comes of age - Nature
2007年8月17日 · The neonatal Fc receptor for IgG (FcRn) is responsible for the transfer of passive humoral immunity from the mother to the newborn in rodents and humans. Throughout life, FcRn contributes to...
Targeting FcRn for immunomodulation: Benefits, risks, and …
2020年9月4日 · The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling mechanism to prevent degradation and extend the half-life of IgG and albumin in the circulation. Several FcRn inhibitors selectively targeting IgG recycling are now moving rapidly toward clinical practice in neurology and hematology.
The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor
2024年8月7日 · We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR-knockout screens with multiple arteriviruses.
A comprehensive review of the neonatal Fc receptor and its ... - PubMed
This review summarizes the main findings on FcRn biology, function and distribution throughout different tissues, together with the main advances on the FcRn-based therapeutic opportunities and model systems, which indicate that this receptor is a …
Neonatal Fc receptor in human immunity: Function and role in ...
The neonatal Fc receptor (FcRn) transports IgG across barriers, for example, the placenta, enhancing fetal humoral immunity to levels similar to their mothers'.
Neonatal Fc receptor in human immunity: Function and role in ...
2020年4月2日 · The neonatal Fc receptor (FcRn) transports IgG across barriers, for example, the placenta, enhancing fetal humoral immunity to levels similar to their mothers’.
The neonatal Fc receptor (FcRn) binds independently to both …
The neonatal Fc receptor (FcRn) is expressed by cells of epithelial, endothelial and myeloid lineages and performs multiple roles in adaptive immunity. Characterizing the FcRn/IgG interaction is fundamental to designing therapeutic antibodies because IgGs with moderately increased binding affinities ….