G-四链体 - 百度百科
G-四链体(G-quadruplex)是由富含串联重复鸟嘌呤(G)的DNA或RNA折叠形成的高级结构。G-四分体(G-quartet)是四链体的结构单元，由Hoogsteen氢键连接4个G形成环状平面，两层或以上的四分体通过π-π堆积形成四链体。
G-quadruplex - Wikipedia
Such a quadruplex is described as tetramolecular, reflecting the requirement of four separate strands. The term G4 DNA was originally reserved for these tetramolecular structures that might play a role in meiosis. [5] However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity.
靶向启动子G-四联体：一种新的抗癌策略？ - 搜狐
2019年1月11日 · 除了传统的dna双螺旋，富含鸟嘌呤的核酸分子还可以形成特殊的g-四联体结构。 本文向大家介绍来自英国剑桥大学癌症研究所 Balasubramanian教授在有关基因启动子中G-四联体的靶向药物研究进展，并讨论其小分子配体作为抗肿瘤药物治疗的临床应用和研究挑战。
G-四联体 - 维基百科，自由的百科全书
G-四联体（英语：G-quadruplex、G-tetrads或G 4-DNA）是一种由富含鸟嘌呤的核酸序列所构成的四股型态。 含有经由 胡斯坦(Hoogsteen) 氢键 维持稳定，并由鸟嘌呤以正方形方式排列而成的结构。
The regulation and functions of DNA and RNA G-quadruplexes
2020年4月20日 · In this Review, we first discuss the identification of G4s and evidence for their formation in cells using chemical biology, imaging and genomic technologies. We then discuss possible functions of...
The Structure and Function of DNA G-Quadruplexes - PMC
Endogenous DNA G-quadruplex (G4) structures have been detected in human cells and mapped in genomic DNA and in an endogenous chromatin context by adapting next-generation sequencing approaches, to reveal cell type- and cell state-specific G4 landscapes and a strong link of G4s with elevated transcription.
The G4 Genome - PMC
We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the genome, which sees DNA as not only a simple alphabet but also a more complex geography.
DNA G-quadruplex structures: more than simple roadblocks to ...
In this review, we will challenge this model depicting G4s as simple ‘off switches’ for gene expression by articulating how their formation has the potential to alter gene expression at many different levels, acting as a key regulatory element perturbing the nature of epigenetic marks and chromatin architecture. Graphical Abstract.
In vivo dynamics and regulation of DNA G-quadruplex structures …
2023年6月28日 · Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed its regulatory dynamics and critical roles in several important biological processes, making eG4 a regulator of gene expression perturbation and a promising therapeutic target in disease biology.
G-quadruplex DNA: a novel target for drug design - PubMed
2021年8月30日 · G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated that G4 DNA structures exist both in cell-free and cellular systems, and function in different diseases, especially in various cancers, aging …