Pancreatic islets - Wikipedia
网页The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. [1] The pancreatic islets constitute 1–2% of the pancreas volume and receive 10–15% of its blood flow. [2] [3] The pancreatic islets are arranged in density …
Islets of Langerhans | Definition, Function, Location, & Facts
网页islets of Langerhans, irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates. They are named for the German physician Paul Langerhans, who first described them in 1869. The normal human pancreas contains about 1 million islets. The islets consist of four major and two minor cell types, of which the major ...
The Cells of the Islets of Langerhans - PMC - National Center for ...
网页2018年3月12日 · Abstract. Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes. Understanding normal islet cell mass and function is important to ...
Pancreatic Islet Transplantation - NIDDK
网页Pancreatic islets contain beta cells that produce the hormone insulin. In the type of islet transplantation used to treat type 1 diabetes, also called islet allo-transplantation, doctors take islets with healthy beta cells from the pancreas of a deceased organ donor. Doctors then inject the healthy islet cells taken from the donor into a vein ...
15.11A: Overview of Pancreatic Islets - Medicine LibreTexts
网页The pancreatic islets are small islands of cells that produce hormones that regulate blood glucose levels. Hormones produced in the pancreatic islets are secreted directly into the bloodstream by five different types of cells. The alpha cells produce glucagon, and make up 15–20% of total islet cells. The beta cells produce insulin and amylin ...
The Human Islet: Mini-Organ With Mega-Impact - PMC
网页2021年4月12日 · This review focuses on the human pancreatic islet—including its structure, cell composition, development, function, and dysfunction. After providing a historical timeline of key discoveries about human islets over the past century, we describe new research approaches and technologies that are being used to study human islets and how these …
Mechanisms controlling pancreatic islet cell function in insulin ...
网页2021年1月4日 · The pancreatic islets of Langerhans were discovered in 1869 by Paul Langerhans as a 21-year-old medical student 1.Each of the several million islets in a human pancreas (range of 1 to 15 million 2 ...
Physiology, Islets of Langerhans - StatPearls - NCBI Bookshelf
网页2022年10月3日 · The islets of Langerhans are clusters of pancreatic cells discovered by Dr. Paul Langerhans, a pathologist who also discovered the dendritic Langerhans cells in 1869.[1] Each islet contains up to a few thousand endocrine cells, and the islets constitute up to 2% of the total pancreatic mass. The islet cells include the alpha cells, beta cells, …
Integrating the inputs that shape pancreatic islet hormone release - Nature
网页2019年12月13日 · The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis. Changes in glucose ...
An integrated single-cell islet atlas in health and disease
网页2023年9月12日 · A mouse pancreatic islet atlas comprising over 300,000 single-cell transcriptomes was integrated from nine biologically diverse datasets to unify existing knowledge in the islet biology community.