mTOR - Wikipedia
The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.
Multifaceted role of mTOR (mammalian target of rapamycin) …
2023年10月2日 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain ...
Mammalian Target of Rapamycin - an overview - ScienceDirect
Mammalian target of rapamycin (mTOR) is a protein kinase involved in regulating cell growth, proliferation, and survival and has been extensively studied in the cancer literature. The mTOR inhibitor rapamycin is used in clinical trials for the treatment of endometrial cancer and soft-tissue and bone sarcomas.
Mammalian Target of Rapamycin (mTOR) Pathways in …
The mammalian target of rapamycin (mTOR) pathway is an essential cellular signaling pathway involved in a number of important physiological functions, including cell growth, proliferation, metabolism, protein synthesis, and autophagy.
mTOR signaling at a glance - PMC - PubMed Central (PMC)
The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. Discoveries that have been made over the last decade show that the mTOR pathway is activated during various cellular processes (e.g. tumor ...
Mammalian Target of Rapamycin - an overview - ScienceDirect
Mammalian target of rapamycin (mTOR) is a serine–threonine kinase involved in almost every aspect of mammalian cell function. This kinase was initially believed to control protein translation in response to amino acids and trophic factors, and this …
Mammalian Target of Rapamycin - an overview - ScienceDirect
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase pathway and has emerged as an attractive cancer therapeutic target because it is a critical player for controlling many cellular processes, e.g., cell growth, proliferation and cell division.
Mammalian target of rapamycin: a central node of complex …
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth and metabolism in response to diverse external stimuli.
Mammalian target of rapamycin (mTOR): conducting the cellular signaling ...
2010年5月7日 · The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2.
The Mammalian Target of Rapamycin: Linking T Cell... : Immunity
In the two-signal model of T cell activation, the outcome of antigen recognition is determined by the integration of multiple cues in the immune microenvironment. mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors.
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