MAPK/ERK pathway - Wikipedia
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
MAPK信号通路成员 - 百度百科
丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）是一组能被不同的细胞外刺激，如细胞因子、神经递质、激素、细胞应激及细胞黏附等激活的丝氨酸-苏氨酸蛋白激酶。
A Comprehensive Review on MAPK: A Promising Therapeutic …
2021年10月22日 · The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic ...
MAPK signal pathways in the regulation of cell proliferation in ...
2002年3月1日 · Mitogen-activated protein kinase (MAPK) cascades have been shown to play a key role in transduction extracellular signals to cellular responses. In mammalian cells, three MAPK...
MAP kinase signaling - My Cancer Genome
The mitogen-activated protein (MAP) kinase cell signaling pathway promotes cell growth, proliferation, and survival. The MAP kinase pathway may be activated via several different routes, including upstream growth factor receptor tyrosine kinases and downstream mutations in pathway gene components.
The MAPK cascades: Signaling components, nuclear roles and …
2011年9月1日 · The mitogen-activated protein kinase (MAPK) cascades are evolutionary conserved, intracellular signal transduction pathways that respond to various extracellular stimuli and control a large number of fundamental cellular processes including growth, proliferation, differentiation, motility, stress response, survival and apoptosis [1], [2], [3 ...
MAPK signaling pathway - Homo sapiens (human) - GenomeNet
Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5.
Understanding MAPK Signaling Pathways in Apoptosis - PMC
In this review, we present the main pro- and anti-apoptotic mechanisms regulated by MAPKs, as well as the crosstalk observed between some MAPKs. We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis.
Function and Regulation in MAPK Signaling Pathways
In this article, we begin with an overview of the MAPK pathways in S. cerevisiae and the mechanisms of their activation in response to signals or stresses. We then discuss the mechanisms by which these pathways regulate downstream molecular and cellular processes.
MAPK Signaling Resources | Cell Signaling Technology
Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.