Selective targeting of visceral adiposity by polycation …
2022年12月1日 · Here we develop a polycation-based nanomedicine polyamidoamine generation 3 (P-G3) that—when delivered intraperitoneally—selectively targets visceral fat due to its high charge density.
Poly(amidoamine) (PAMAM): An emerging material for
2016年2月1日 · Poly (amidoamine) (PAMAM) dendrimers have received attention due to their large surface areas with high concentration of functional end groups to bind biological material. They are monodisperse and hyper-branched polymers which include active functional groups outside its surface.
(PDF) Poly(amidoamine) (PAMAM) Dendrimers: Synthesis and …
2020年5月20日 · Poly (amidoamine) (PAMAM) dendrimers are the most intensively studied class of dendrimers since the seminal report of Tomalia et al. in 1985.
Polyamidoamines: Versatile Bioactive Polymers with Potential …
2019年2月7日 · Polyamidoamines (PAAs) are multifunctional polymers prepared from prim - or sec -amines by Michael-type polyaddition with bisacrylamides. The reaction is preferably carried out at room temperature in water and without added catalysts or …
Poly(amidoamine) dendrimers: covalent and ... - ScienceDirect
2019年9月1日 · Among all the reported dendrimers, poly (amidoamine) (PAMAM) dendrimers are the most extensively studied by virtue of their readily availability via robust synthesis as well as their dendritic structure and peptide/protein mimic features.
PAMAM dendrimers as efficient drug and gene delivery …
Polyamidoamine (PAMAM) dendrimers are an example of a versatile and reproducible type of nanocarrier that can be loaded with drugs, and modified by attaching target-specific ligands that recognize receptors that are over-expressed on cancer cells.
Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to …
2001年4月15日 · Poly (amidoamine) (PAMAM) dendrimers are the first complete dendrimer family to be synthesized, characterized and commercialized. Based on this extensive activity, they are recognized as a unique new class of synthetic nanostructures.
Use of Polyamidoamine Dendrimers in Brain Diseases - MDPI
2018年9月3日 · Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases.
Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery …
2024年7月15日 · Polyamidoamine (PAMAM) dendrimers, as branched macromolecular architectures, represent promising candidates for studies in glioma therapy. This review focuses on PAMAM-based DDSs in the treatment of glioma, highlighting their physicochemical characteristics, structural properties as well as an overview of the toxicity and safety profiles.
Fluorinated polyamidoamine dendrimer-mediated miR-23b …
2023年2月20日 · Here, a fluorinated polyamidoamine dendrimer (FP) is used to deliver miR-23b to reduce inflammation by triggering the apoptosis of as well as inhibiting the inflammatory response in macrophages.
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