Pathophysiology of Type 2 Diabetes Mellitus - PMC - PubMed …
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin.
Mechanisms underlying the pathophysiology of type 2 diabetes…
2022年2月1日 · Type 2 diabetes development involves a vicious cycle of complex metabolic alterations. Mitochondrial dysfunction and disturbances in insulin signaling are crucial in T2D. Physical exercises and nutritional interventions delay the progression of diabetes. Type 2 diabetes and Alzheimer’s disease share common features and signaling pathways.
Pathophysiology of Type 2 Diabetes Mellitus - PubMed
2020年8月30日 · This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on ...
Diabetes mellitus: From molecular mechanism to …
2023年9月1日 · The pathophysiology of type 2 diabetes mellitus is distinguished by insulin deficiency and insulin resistance, which have been linked to inflammatory cytokines in the plasma and high levels of fatty acids, leading to deficient glucose transport into target cells, elevated breakdown of fat, and increased hepatic glucose production [29 ...
Type 2 diabetes mellitus in adults: pathogenesis, prevention and ...
2024年10月2日 · In this review, we aim to summarize the underlying mechanism, screening, diagnosis, prevention, and treatment of T2D, especially regarding the personalized selection of hypoglycemic agents and...
Pathogenesis of Type 2 Diabetes Mellitus - Endotext - NCBI Bookshelf
2021年9月27日 · In turn, the combined effects of insulin and hyperglycemia to promote glucose disposal are dependent on three tightly coupled mechanisms: (i) suppression of endogenous (primarily hepatic) glucose production; (ii) stimulation of glucose uptake by the splanchnic (hepatic plus gastrointestinal) tissues; and (iii) stimulation of glucose uptake by pe...
The integrative biology of type 2 diabetes - Nature
2019年12月5日 · Here we summarize recent studies providing insights into insulin resistance and increased hepatic gluconeogenesis associated with obesity and type 2 diabetes, focusing on data from humans and...
Mechanisms underlying the pathophysiology of type 2 diabetes …
Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the combination of genetic and environmental factors, and obesity, lifestyle, and aging are the most relevant risk factors. Hyperglycemia is the main metabolic feature of T2D as a consequence of insulin resistance and β-cell …
Epigenetics of the Pathogenesis and Complications of Type 2 Diabetes ...
Epigenetics of type 2 diabetes mellitus (T2DM) has widened our knowledge of various aspects of the disease. The aim of this review is to summarize the important epigenetic changes implicated in the disease risks, pathogenesis, complications and the evolution of therapeutics in our current understanding of T2DM.
Molecular and metabolic mechanisms of insulin resistance and …
β-cell failure of type 2 diabetes has a metabolic component, wherein exposure to excess lipids abrogates the normal glucose-induced increase in pyruvate cycling. Overnutrition causes a demand...