- To heal chafing at home, first, clean the affected area completely with mild soap and water. After you’ve cleaned and dried the infected area, apply an aloe vera gel. Aloe vera may help relieve any pain and prevent further infection. Then, apply a layer of petroleum jelly to help heal irritation and prevent the chafing from getting any worse.my.clevelandclinic.org/health/diseases/23517-chafing
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