Platelet-activating factor acetylhydrolases: An overview and …
Platelet-activating factor acetylhydrolases (PAF-AHs) are unique members of the phospholipase A 2 family that can hydrolyze the acetyl group of PAF, a signaling phospholipid that has roles in diverse (patho)physiological processes.
To hydrolyze or not to hydrolyze: the dilemma of platelet …
However, all of them are hydrolyzed to the biologically inactive lysoPAF/lysophosphatidylcholine (lysoPC) metabolites by a family of enzymes called PAF acetylhydrolase (PAF-AH) (1 – 4).
The emerging roles of PAF acetylhydrolase - PMC
Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs).
Platelet-activating factor acetylhydrolases: An overview and …
2019年6月1日 · Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor Biochem.
Platelet-activating factor acetylhydrolases: An overview and …
2019年6月1日 · Platelet-activating factor acetylhydrolases (PAF-AHs) are unique members of the phospholipase A 2 family that can hydrolyze the acetyl group of PAF, a signaling phospholipid that has roles in diverse (patho)physiological processes.
Platelet-activating factor acetylhydrolase (PAF-AH) - PubMed
Platelet-activating factor (PAF) is one of the most potent lipid messengers involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity, and its deacetylation induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH).
Platelet-activating Factor Acetylhydrolases - Journal of Biological ...
Platelet-activating factor acetylhydrolases are structurally diverse isoenzymes that catalyze the hydrolysis of the acyl group at the second position of glycerol in unusual, bioactive phospholipids (Fig. 1).
To hydrolyze or not to hydrolyze: the dilemma of platelet …
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Platelet-Activating Factor Acetylhydrolase (Pafah)
2018年1月1日 · Platelet activating factor-acetylhydrolases (PAF-AH) (EC 3.1.1.47) are essentially phospholipase A 2 isoenzymes (Group VII and VIII) catalyzing the hydrolysis of short chain acyl group at the second position of phospholipids.
Platelet-activating factor acetylhydrolases in health and disease
2000年10月31日 · PAF acetylhydrolase Ib is a heterotrimeric protein composed of two α and one β subunit. The complex has received much attention in part because the subunit that modulates enzymatic activity (the β subunit) is the product of the LIS1 gene.