Camptothecin's journey from discovery to WHO Essential ... - PubMed
2021年11月5日 · Camptothecin (CPT), isolated from the bark of Camptotheca acuminata, is a cytotoxic alkaloid that attenuates cancer cell replication by inhibiting DNA topoisomerase 1. Despite its promising and wide spectrum antipr …
Camptothecin | C20H16N2O4 | CID 24360 - PubChem
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
The long story of camptothecin: From traditional medicine to …
2017年2月15日 · 20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions.
Camptothecin: Uses, Interactions, Mechanism of Action
2007年9月11日 · Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of...
Camptothecin and its derivatives: Advancements, mechanisms …
2024年10月9日 · Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated significant anticancer properties in a range of malignancies. However, its therapeutic efficacy is limited by its hydrophobicity, poor bioavailability, and systemic toxicity.
Camptothecin's journey from discovery to WHO Essential Medicine…
2021年11月5日 · Camptothecin (CPT), isolated from the bark of Camptotheca acuminata, is a cytotoxic alkaloid that attenuates cancer cell replication by inhibiting DNA topoisomerase 1. Despite its promising and wide spectrum antiproliferative activity, its use is limited due to low solubility, instability, acquired tumour cell resistance, and remarkable toxicity.
Definition of camptothecin - NCI Drug Dictionary - NCI
camptothecin An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double ...
Camptothecin - an overview | ScienceDirect Topics
Camptothecin (CPT; Fig. 2) is an anticancer drug that damages DNA, leading to cell destruction. Its therapeutic efficacy is limited by very low water solubility and adverse side effects such as inflammation of the urinary bladder.
Review camptothecin: current perspectives - PubMed
The review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor agent that targets topoisomerase I. Thousands of CPT derivatives have been synthesized.
The long story of camptothecin: From traditional medicine to drugs
2017年2月15日 · 20-(S)-Camptothecin (CPT) is a natural alkaloid extracted from the bark of Camptotheca acuminata (Chinese happy tree). It acts as a DNA topoisomerase 1 poison with an interesting antitumor activity and its use is limited by low stability and solubility and unpredictable drug-drug interactions.
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