Late-Stage Functionalization: Chem - Cell Press
2020年8月6日 · The term late-stage functionalization (LSF) is recent but is now frequently used in the field of organic methodology development to describe transformations on complex molecules. Such reactions include catalytic and non-catalytic reactions, C–H functionalizations, and functional-group manipulations with one or several desired products.
Late-Stage Functionalization - ScienceDirect
2020年8月6日 · Our definition of late-stage functionalization (LSF) resolves previous ambiguity associated with the term and should help chemists to classify reactions as LSF or not. For LSF reactions, chemoselectivity is a requirement, whereas …
We define late-stage functionalization (LSF) as follows: LSF is a desired chemoselec-tive transformation on a complex molecule to provide at least one analog in suffi-cient quantity and purity for a given purpose without the necessity for installation of a functional group that exclusively serves the purpose to enable said transforma-tion.
[PDF] Late-Stage Functionalization - Semantic Scholar
2020年8月1日 · The late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen is reported, illustrated by the modification of a series of medicinally important compounds, as well as the increase in efficiency of synthesis of several existing pharmaceuticals.
Late-Stage Functionalization of Living Organisms: Rethinking ...
In this way, we explore a concept of late-stage functionalization of living organisms (where “late” is taken to mean at a given state of an organism in time) in which programmed and selective chemical reactions take place in life. ... Jonas C. R.; Ziegler T. R.; Gu L. i. H.; Jones D. P. Extracellular thiol/disulfide redox state affects ...
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Late-Stage Functionalization (A) Examples of LSF reactions. (B) LSF versus chemoselective reaction on a complex molecule. TFA, trifluoroacetic acid; PEG, polyethylene glycol.
Late-stage Functionalization for Improving Drug-like Molecular ...
2023年6月7日 · The development of late-stage functionalization (LSF) methodologies, particularly C–H functionalization, has revolutionized the field of organic synthesis. Over the past decade, medicinal chemists have begun to implement LSF strategies into their drug discovery programs, allowing for the drug discovery process to become more efficient.
Late-Stage Functionalization,Chem - X-MOL
The term late-stage functionalization (LSF) is recent but is now frequently used in the field of organic methodology development to describe transformations on complex molecules. Such reactions include catalytic and non-catalytic reactions, C–H functionalizations, and functional-group manipulations with one or several desired products.
Late-stage functionalization - Wikipedia
Late-stage functionalization (LSF) is a desired, chemical or biochemical, chemoselective transformation on a complex molecule to provide at least one analog in sufficient quantity and purity for a given purpose without needing the addition of a functional group that exclusively serves to enable said transformation.
(PDF) Late-stage Functionalization and its Impact on Modern …
2022年3月30日 · This Review highlights the significant advances achieved in the late-stage C–H functionalization of drugs and drug-like compounds, and showcases how the implementation of these modern...