AMP-activated protein kinase - Wikipedia
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.
AMP-activated protein kinase: the current landscape for drug ...
Mar 13, 2019 · AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis that is activated by physiological regulators associated with health and longevity.
The AMP-activated protein kinase (AMPK) signaling pathway ...
AMPK is a highly conserved sensor of intracellular adenosine nucleotide levels that is activated when even modest decreases in ATP production result in relative increases in AMP or ADP. In response, AMPK promotes catabolic pathways to generate …
New insights into activation and function of the AMPK - Nature
Oct 31, 2022 · The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios.
AMPK: guardian of metabolism and mitochondrial homeostasis
Oct 4, 2017 · AMP-activated protein kinase (AMPK) is a highly conserved sensor of low intracellular ATP levels that is rapidly activated after nearly all mitochondrial stresses, even those that do not...
AMPK activators: mechanisms of action and physiological ...
Apr 1, 2016 · AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand.
AMPK: restoring metabolic homeostasis over space and time
AMP-activated protein kinase (AMPK) is the primary sensor of cellular energy through adenine nucleotide levels that evolved and is maintained across all eukaryotic organisms. AMPK senses the energetic content of the cell through direct interactions with ATP, ADP, and AMP.
AMP-activated protein kinase: a key regulator of energy ...
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that regulates cellular and whole body energy balance. A recent crystal structure has illuminated the complex regulatory mechanisms by which AMP and ADP cause activation of AMPK, involving phosphorylation by the upstream kinase, LKB1.
AMPK: Sensing Glucose as well as Cellular Energy Status
Mammalian 5′-AMP-activated protein kinase (AMPK) is usually regarded as a sensor of adenine nucleotides that is activated in states of low cellular energy, and acts to restore energy balance under those circumstances by switching on alternative catabolic pathways that generate ATP while switching off anabolic pathways and other processes ...
Regulation and function of AMPK in physiology and diseases
Jul 15, 2016 · 5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that was originally identified as the key player in maintaining...