Lipolysis: cellular mechanisms for lipid mobilization from fat …
2021年11月19日 · The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARγ. Am. J. Physiol. Endocrinol.
Fat Mobilization in Adipose Tissue Is Promoted by Adipose
2004年11月19日 · Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue.
Adipose triglyceride lipase and the lipolytic catabolism of cellular ...
2009年1月1日 · In vertebrates, FAs are predominantly stored in the form of triacylglycerol (TG) within lipid droplets of white adipose tissue. Lipid droplet-associated TGs are also found in most nonadipose tissues, including liver, cardiac muscle, and skeletal muscle. The mobilization of FAs from all fat depots depends on the activity of TG hydrolases.
The role of adipose triglyceride lipase in lipid and glucose ...
2019年11月22日 · The discovery of adipose triglyceride lipase (ATGL) as a triglyceride lipase provided a heightened understanding of the mechanisms governing mobilization of fat reserves from adipose tissue. ATGL catalyses the initial step in adipose triglyceride lipolysis, working in concert with other enzymes to mobilize triglyceride for energy production.
Triacylglycerol metabolism in adipose tissue - ScienceDirect
2003年1月1日 · This chapter provides an overview of triacylglycerol metabolism in adipose tissue. There are two types of adipose tissue, distinguished histologically and functionally: brown adipose tissue (BAT) and white adipose tissue (WAT). They have in common cells (adipocytes) that store lipid in the form of triacylglycerol (TG).
Adipose triglyceride lipase-mediated lipolysis of cellular fat …
2006年5月1日 · Antisense RNA-mediated reduction of CGI-58 expression in 3T3-L1 adipocytes inhibits TG mobilization. Finally, expression of functional CGI-58 in CDS fibroblasts restores lipolysis and reverses the abnormal TG accumulation typical for CDS.
Adipose triglyceride lipase mediates lipolysis and lipid mobilization ...
2022年3月3日 · In response to dietary iron-induced negative energy balance, adipose triglyceride lipase (ATGL) was necessary for wasting of subcutaneous white adipose tissue and lipid mobilization. Fat-specific ATGL deficiency protected mice from fat wasting, but caused a severe cachectic response in mice when fed iron.
(PDF) Fat Mobilization in Adipose Tissue Is Promoted by Adipose ...
2004年12月1日 · Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of...
Fat mobilization in adipose tissue is promoted by adipose
2004年11月19日 · Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue.
Transcriptional determinants of lipid mobilization in human
2024年1月3日 · White adipose tissue (WAT) stores triglycerides by lipogenesis and mobilizes these lipids via lipolysis. The latter is a tightly controlled process involving stepwise hydrolysis reactions catalyzed by adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monoglyceride lipase .
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