Angiotensin II and the Heart | Hypertension - AHA/ASA Journals
2000年6月1日 · We also discuss renin- and ACE-dependent generation of Ang II at cardiac tissue sites and the evidence that there is an intracrine RAS in the heart. Ang II generation through alternative pathways (eg, through cathepsin D, tonin, or chymase) as well as the cardiac effects of other angiotensin metabolites, eg, Ang III, Ang IV, and Ang-(1-7), and ...
Role of cardiac overexpression of ANG II in the regulation of …
Using transgenic mice with cardiac-specific expression of a fusion protein that releases an ANG II peptide (Tg-ANG II-cardiac) independently of the RAS, we found that overexpression of ANG II in the heart caused interstitial fibrosis under basal conditions without affecting heart …
Effects of Empagliflozin and Dapagliflozin in alleviating cardiac ...
18 小时之前 · Construction of Ang II/TGF-β1-induced myocardial fibrosis model in vitro. (A, B) The effect of varying Ang II concentrations (0.01, 0.1, 1 µM) on cardiac fibroblasts (CFs) proliferation rates at ...
New Take on the Role of Angiotensin II in Cardiac Hypertrophy …
2011年4月18日 · Elevated cardiac Ang II enhanced cardiac myocyte apoptosis, macrophage infiltration, and expression of NADPH oxidase (NOX) 2 and transforming growth factor-β 1 (TGF-β 1), whereas protective signaling was downregulated. Ang II and TGF-β 1 induce NADPH oxidase activity, which is implicated in cardiac fibrosis 6 and hypertrophy. 7
Lycorine inhibits Ang II-induced heart remodeling and …
2024年6月1日 · Ang II induces hypertensive heart failure (HF) via hemodynamic and non-hemodynamic actions. Lycorine (LYC) is an alkaloid derived from Lycoris bulbs, and it possesses anti-cardiovascular disease-related activities. Herein, we explored the potential LYC-mediated regulation of Ang II-induced HF.
Angiotensinogen: - JACC: Heart Failure
In addition to playing a role as a robust biomarker of acute disease, angiotensinogen stands to play a role in management of both heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. Ang II escape in heart failure management with current RAAS inhibitors is a well-documented phenomenon, and dual RAAS ...
Angiotensin II, From Vasoconstrictor to Growth Factor:
2014年2月28日 · Ang II is now known to be a pleiotropic hormone that uses multiple signaling pathways to influence most processes that contribute to the development and progression of cardiovascular diseases, ranging from hypertrophy, endothelial dysfunction, cardiac remodeling, fibrosis, and inflammation to oxidative stress.
Characterization of a robust mouse model of heart failure with ...
2023年8月1日 · Using a continuous infusion of angiotensin II and phenylephrine (ANG II/PE), we demonstrate a strong HFpEF phenotype satisfying major clinically relevant manifestations and criteria of this pathology, including exercise intolerance, pulmonary edema, concentric myocardial hypertrophy, diastolic dysfunction, histological signs of microvascular ...
Angiotension II directly bind P2X7 receptor to induce myocardial ...
2024年6月1日 · In our study, we provide (1) strong evidence of the pivotal role of P2X7R in Ang II-induced cardiac ferroptosis and remodeling through direct Ang II binding, (2) an in-depth description of how Ang II enhances myocardial ferroptosis and thus contributes to cardiac dysfunction, and (3) evidence that P2X7R could become a promising novel target for ...
Comparison of mouse models of heart failure with reduced ejection fraction
2024年9月7日 · Compared with the well-established TAC model, chronic Ang-II treatment of Balb/c mice shares similarities in cardiac systolic functional decline (left ventricular ejection fraction: −57.25 ± 7.17% vs. −43.68 ± 5.31% in ΔTAC vs. ΔAng-II; P = 0.1794) but shows a lesser degree of left ventricular dilation (left ventricular end-systolic ...
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