Antipyretics: mechanisms of action and clinical use in fever ...
We review here the mechanisms of commonly used antipyretics, emphasizing their ability to block the febrile response at multiple sites along a physiologic cascade that connects peripheral inflammation with the central nervous system, and conclude with some thoughts on the proper use of antipyretics for patients with fever.
Antipyretics: mechanisms of action and clinical use in fever ...
The predominant mode of action of antipyretic drugs involves reducing central nervous system concentrations of prostaglandin E 2 by directly inhibiting cyclooxygenase. Another postulated mechanism involves suppressive effects on inflammatory gene expression.
Antipyretic Therapy: Physiologic Rationale, Diagnostic …
Antipyretic therapy might also be justified, at least in theory, if fever's metabolic cost exceeded its physiologic benefit, if the treatment provided symptomatic relief without adversely affecting the course of the febrile illness, and/or if the toxicologic costs (adverse effects) of the antipyretic regimen were appreciably lower than its ...
Antipyretic - Wikipedia
The most common antipyretics in the US are usually ibuprofen and aspirin, which are nonsteroidal anti-inflammatory drugs (NSAIDs) used primarily as anti-inflammatories and analgesics (pain relievers), but which also have antipyretic properties; and paracetamol (acetaminophen), an analgesic without anti-inflammatory properties.
Comprehensive biology of antipyretic pathways - ScienceDirect
2019年4月1日 · Peripheral endogenous antipyretic action is mediated by antipyretic cytokines, glucocorticoids; Spleen derived anti-hyper pyretic lipid factors and several other hormones. Centrally active antipyretics include eicosanoids, neuropeptides, nitric oxide and other gaseous neurotransmitters.
Phillyrin and its metabolites exert antipyretic effects by targeting ...
2024年11月1日 · The antipyretic effect of Phr, the main pharmacodynamic ingredient of Lian Qiao, is related to its metabolites Phg and Phg-S, which target the NAD +-binding domain of GAPDH, IDH2, and MDH2, thereby inhibiting enzyme activity and energy metabolism. This study provides a new perspective for improving the treatment of fever.
Central mediators involved in the febrile response: effects of ...
2021年10月15日 · In this review, we discuss recent data on the importance of prostaglandins in the febrile response, and we show that some endogenous mediators can still induce the febrile response even when known antipyretics reduce the levels of …
Use of analgesics/antipyretics in the management of symptoms
2022年3月2日 · Analgesics and antipyretics, such as acetaminophen (paracetamol) and non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen), have been routinely used for decades to manage acute side...
Physiology, Fever - StatPearls - NCBI Bookshelf
2023年9月4日 · Other mechanisms of antipyretics have been suggested, which include reduction in proinflammatory mediators and enhancement of anti-inflammatory signals at the site of injury. While one may feel inclined to give an antipyretic to all febrile patients, this is not recommended.
Molecular mechanisms of fever and endogenous antipyresis
Supporting a role for P-450 in endogenous antipyresis and antiinflammation includes evidence that (1) inducers of P-450 reduce fever, (2) inhibitors of P-450 cause a larger fever, (3) and P-450 arachidonic acid metabolites reduce fever. This review summarizes recent studies on endogenous antipyretic mechanisms.
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