Structures Common to Different Glycans - Essentials of …
The A, B, and H blood group antigens are glycans presented on Type-1 or Type-2 structures (Figure 14.2), on O-GalNAc glycans (Type-3), or on glycolipids (Type-4) (Figure 14.4). The blood group antigens are formed by the sequential action of glycosyltransferases encoded by the ABO, H, and Se genes, now termed the ABO, FUT1, and FUT2 loci (Figure ...
ABO blood group antigens and differential glycan expression ...
2023年1月20日 · The ABO blood group system contains the A, A 1, B, and A,B antigens, whereas the H blood group system contains the H antigen, which is the precursor for the others (ISBT, 2021). A and B structures are added to type 1 and 2 H chains. Blood group O individuals cannot synthesize A or B antigens, and so they only express the H antigen.
ABO blood group antigens and differential glycan expression ...
2023年1月1日 · Genetic variants and defects in the enzymes responsible for the biosynthesis of glycans or their monosaccharide precursors can lead to reduced or complete absence of particular glycans. The ABO(H) blood groups are carbohydrate based, and each individual has a specific blood type, e.g, A, B, AB, or O.
The relationship between ABO blood group, von Willebrand …
2020年12月17日 · Although ABO blood group determinants are not carried on the N-glycans of platelet-VWF, studies have shown that they are expressed on the surface of several platelet membrane glycoproteins and glycolipids. 92 Among the glycoproteins that express ABH antigens are GPIb, IIa, IIIa, IV, and V, as well as platelet EC adhesion molecule-1 (PECAM-1 ...
ABO blood group antigens and differential glycan expression ...
2022年12月14日 · In this review, we examine the enzymes responsible for carbohydrate-based blood group antigen biosynthesis and their expression within the human population. We also consider the evolutionary selective pressures, e.g. malaria, that may account for the variation in carbohydrate structures and the implications of this biology for human disease.
ABO blood group glycans modulate sialic acid recognition on ...
2009年10月22日 · ABH(O) blood group polymorphisms are based on well-known intraspecies variations in structures of neutral blood cell surface glycans in humans and other primates. Whereas natural antibodies against these glycans can act as barriers to blood transfusion and transplantation, the normal functions of this long-standing evolutionary polymorphism ...
Glycans in Systemic Physiology - Essentials of Glycobiology - NCBI ...
ABO blood group antigens on human erythrocytes are glycans, and successful blood transfusion requires compatibility of these antigens between donor and recipient (Chapter 14). Glycans on glycoproteins (e.g., integrin GPIIb/IIIa [CD41/CD61]) on the surfaces of circulating platelets play key roles in hemostasis.
Synthesis of glycans functioning as antigens of the ABO blood group ...
2019年11月1日 · The first one is the removal of recipient antibodies during ABO-mismatched transplantation using Sepharose with immobilized glycans A and B,6 and the second one is ABO blood typing, where synthetic glycolipids A and B are embedded in blood group O erythrocytes and as a result the erythrocytes with a standard content of A or B antigen are ...
Multifaceted role of glycosylation in transfusion medicine, platelets ...
2020年4月30日 · A and B glycosyltransferases convert the H antigen (present in blood group O individuals) to blood group A or B, respectively. These A and B antigens can be found on the membrane surface as glycoproteins or glycolipids or they …
Clinical impact of glycans in platelet and megakaryocyte biology
2022年6月2日 · Glycans and glycan-binding receptors (lectins) regulate cell-cell interactions, cell adhesion, migration, immune responses, and self/nonself-recognition, best exemplified by the ABO blood group system. Glycans, classified according to the glycosidic bond as N or O linked, add to biologic complexity by cell-specifically modifying the biologic ...