The radiobiological principles of boron neutron capture therapy: …
2011年12月1日 · The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor.
硼中子俘获治疗的生物学机制及临床研究进展 - cjrmp.net
2023年10月14日 · 硼中子俘获治疗(boron neutron capture therapy, BNCT)是一种新型且高度精准的肿瘤放疗手段。BNCT可依赖高效靶向的含硼药物, 在细胞级别同时实现对肿瘤细胞的精准打击和对正常细胞的精准防护。含硼药物研发正在深入进行, 新型高效的制剂层出不穷, 这为充分发 …
DNA‐damage RBE assessment for combined boron and gadolinium neutron …
2024年5月20日 · Neutron capture therapy (NCT) by 10B and 157Gd agents is a unique irradiation‐based method which can be used to treat brain tumors. Current study aims to quantitatively evaluate the relative biological effectiveness (RBE) and dose distributions during the combined BNCT and GdNCT modalities through a hybrid Monte Carlo (MC) simulation approach.
Novel promising boron agents for boron neutron capture therapy…
2024年7月15日 · Boron Neutron Capture Therapy (BNCT) is an emerging binary radiation therapy that exhibits high precision and lethlity for tumor. Its clinical efficacy has been demonstrated in locally aggressive tumors (glioma, melanoma, osteosarcoma, etc.).
Microdosimetric Modeling of Biological Effectiveness for Boron Neutron …
2018年1月17日 · Neutron capture therapy using the 10 B (n, α) 7 Li reaction, BNCT, is one of the most effective therapeutic modalities for treating locally invasive malignant tumors thanks to the large...
RBE in fast neutron therapy and in boron neutron capture therapy…
In fast neutron therapy, an operational approach has been adopted which is based on the concept of "clinical RBE". The paper discusses the quantities of RBE (relative biological effectiveness), reference RBE and clinical RBE and their relationship and significance in radiation therapy.
Assessing the biological effects of boron neutron capture therapy ...
Background: Boron neutron capture therapy (BNCT) is a targeted radiotherapy that relies on the 10 B (n, α) 7 Li reaction, which produces secondary particles with high linear energy transfer (LET), leading to a high relative biological effectiveness (RBE) in tumors.
Assessment of biological effectiveness of boron neutron capture therapy ...
Purpose: In order to optimize the effectiveness of Boron Neutron Capture Therapy (BNCT), Relative Biological Effectiveness (RBE) and Compound Biological Effectiveness (CBE) were determined in two human melanoma cell lines, M8 and Mel-J cells, using the amino acid p-boronophenylalanine (BPA) as boron carrier.
Boron Neutron Capture Therapy: Application of Radiobiological ...
2012年1月1日 · Recoil protons vary in their relative biological effectiveness (RBE) as a function of neutron energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this component of the dose. Protons, of the energy produced by …
Assessing the biological effects of boron neutron capture therapy ...
2024年10月10日 · Boron neutron capture therapy (BNCT) is a targeted radiotherapy that relies on the 10 B (n, α) 7 Li reaction, which produces secondary particles with high linear energy transfer (LET), leading to a high relative biological effectiveness (RBE) in tumors.