Targeting of CD163 + Macrophages in Inflammatory and …
网页2020年7月31日 · Both ADC’s and pegylated stealth liposomes have been targeted towards CD163 + macrophages using anti-CD163 immunoglobins in in vivo animal models of inflammatory and malignant diseases. Furthermore, anti-CD163 antibodies have been demonstrated as potential traces for bioimaging of CD163 + macrophages in diagnosis and progression of diseases.
Differential association of CD68+ and CD163+ macrophages with …
网页2020年8月26日 · Intratumoural CD163 + macrophage infiltration was positively correlated to Breslow depth (c), while intratumoural CD68 + macrophage infiltration showed no significant correlation (d).
Targeting of CD163 + Macrophages in Inflammatory and …
网页2020年7月31日 · The use of antibodies for directing anti-inflammatory (e.g., glucocorticoids) or tumoricidal (e.g., doxorubicin) drugs to CD163 + macrophages in animal models of inflammation and cancer has demonstrated a high efficacy of the conjugate drugs. This macrophage-targeting approach has a low toxicity profile that …
CD163 as a marker of M2 macrophage, contribute to predict ...
网页2017年3月3日 · CD163 is confirmed to be a phenotypic marker of M2 macrophages that can be used to distinguish M2 and M1 macrophages. In this study, we found that CD163-positive M2 macrophages were primarily located in the tumor stroma, a few also distrbuted in the tumor islet of Kazkah ESCCs.
CD163 and Inflammation: Biological, Diagnostic, and Therapeutic …
网页2013年6月6日 · The nonshed membrane form of CD163 in macrophages constitutes a target for drugs to be directed to macrophages in inflammation. This approach has been used in an animal inflammation model to highly increase the apparent therapeutic index of anti-inflammatory glucocorticoid drug that was coupled to an anti-CD163 antibody.
The macrophage scavenger receptor CD163 - PubMed
网页CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin:Haptoglobin complexes.
CD163 and inflammation: biological, diagnostic, and ... - PubMed
网页2013年6月10日 · The nonshed membrane form of CD163 in macrophages constitutes a target for drugs to be directed to macrophages in inflammation. This approach has been used in an animal inflammation model to highly increase the apparent therapeutic index of anti-inflammatory glucocorticoid drug that was coupled to an anti-CD163 antibody.
CD163+ macrophages are associated with a vulnerable plaque
网页2020年9月1日 · Macrophages expressing CD163 are associated with intraplaque hemorrhage and have previously been considered atheroprotective. However, in a recent study CD163-deficient atherosclerotic...
The macrophage scavenger receptor CD163: endocytic properties …
网页2006年1月24日 · CD163 is the monocyte/macrophage-specific receptor for haptoglobin-hemoglobin (Hp-Hb) complexes. The cytoplasmic tail of human CD163 exists as a short tail variant and two long tail variants. Reverse transcriptase-polymerase chain reaction analysis indicated that all three CD163 variants are substantially expressed in …
The Role of Soluble CD163 (sCD163) in Human Physiology and
网页2 天之前 · Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome, consisting of almost the entire extracellular domain, of the CD163, a receptor expressed in monocytic lineages. Its expression is proportional to the abundance of CD163+ macrophages. Various mechanisms trigger the ...