Therapeutic approaches targeting CD95L/CD95 signaling in
2022年3月17日 · The role of this caspase in apoptosis induction by CD95L and TRAIL, and in particular its ability to substitute to caspase-8 loss, has been controversed.
Differential regulation of TRAIL and CD95 ligand in ... - PubMed
TRAIL (APO-2 ligand) and CD95L (CD95/APO-1/Fas ligand) share the highest homology among the TNF family members and the ability to induce apoptosis. These similarities raise the issue of a potential functional redundancy between the two ligands. We have previously shown that CD95L-resistant cells may be sensitive to TRAIL, even though apoptosis ...
The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis
CD95, also called Fas, is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its ligand, CD95L, was initially detected at the plasma membrane of activated T-lymphocytes and natural killer (NK) cells where it contributes to the elimination of transformed and infected cells.
The role of CD95 and CD95 ligand in cancer - Nature
2015年2月6日 · CD95 and CD95L were discovered to be critical survival factors for cancer cells, and were found to protect and promote cancer stem cells. We now discuss five different ways in which inhibiting or...
Enforced covalent trimerization increases the activity of the …
2007年8月17日 · Variants of human TRAIL (hTRAIL) and human CD95L (hCD95L), encompassing the TNF homology domain (THD), interact with the corresponding receptors and stimulate CD95 and TRAILR2 signaling after...
CD95L and Anti-Tumor Immune Response: Current Understanding …
2021年3月16日 · The emerging evidence to support the role of CD95/CD95L signaling in the anti-tumor immune response will be presented in the context of various malignancies and the modalities of potential therapeutic interventions via selective CD95L inhibition in combination with traditional interventions such as RT, chemotherapy and immune checkpoint inhibitors.
CD95L/FasL and TRAIL in tumour surveillance and cancer therapy
The membrane-bound death ligands CD95L/FasL and TRAIL, which activate the corresponding death receptors CD95/Fas, TRAILR1 and TRAILR2, induce apoptosis in many tumour cells, but can also elicit an inflammatory response. This chapter focuses on the relevance of CD95L/FasL and TRAIL for the tumour sur ….
CD95L/FasL and TRAIL in Tumour Surveillance and Cancer Therapy …
2024年3月7日 · The membrane-bound death ligands CD95L/FasL and TRAIL, which activate the corresponding death receptors CD95/Fas, TRAILR1 and TRAILR2, induce apoptosis in many tumour cells, but can also elicit an inflammatory response. This chapter focuses on the relevance of CD95L/FasL and TRAIL for the tumour surveillance function of natural killer cells and ...
Cell death‐independent activities of the death receptors ... - FEBS …
2016年11月19日 · CD95L- and TRAIL-induced inflammation in vivo. The production of various cytokines and chemokines, such as IL6, IL8, CXCL1, and MCP1, has been repeatedly reported for CD95L- and TRAIL-treated cell death-competent cells. The relevance of this apoptosis-associated mode of NFκB/inflammatory signaling, however, is poorly understood.
Role of metalloproteases in the CD95 signaling pathways
2022年12月4日 · The transmembrane CD95L (m-CD95L) triggers cell death when it interacts with CD95-expressing cells, while metalloproteases can release soluble CD95L (s-CD95L) (46–48). Expressed by activated B and T-cells, m-CD95L contributes to the immune contraction ( 49 ) and its expression by myeloid cells participates in tissue inflammation by recruiting ...