Integrating Cellular Dimensions with Cell Differentiation During …
(a) A cell size threshold dictates onset of ZGA during Xenopus early embryo development and a cell size gradient shapes the spatially graded pattern of gene expression in single embryos at blastula stage . Proposed mechanisms include increased DNA:cytoplasm or nucleocytoplasmic (N:C) ratio and potential titrations of inhibitory proteins relative to DNA [14,15,63].
Cell Proliferation in Development and Differentiation
Early development is characterized by the rapid proliferation of embryonic cells, which then differentiate to produce the many specialized types of cells that make up the tissues and organs of multicellular animals.
Integrating Cellular Dimensions with Cell Differentiation During …
In this review, we summarize recent advances that elucidate the contribution of the physical dimensions of a cell to major embryonic transitions and cell fate specification in vivo. We also highlight techniques and newly evolving methods for manipulating the sizes and shapes of cells and whole embryos in situ and ex vivo.
Signaling in Cell Differentiation and Morphogenesis - PMC
In this article, I review some of the signaling pathways that play essential roles during embryonic development. These examples show some of the mechanisms used by cells to receive and interpret developmental signals.
Signalling dynamics in embryonic development - PMC - PubMed …
Communication between cells coordinates the self-organization process of embryonic development. Cell proliferation, differentiation, migration and death have to be regulated across scales — from single-cell to organism level — to allow the formation of …
Cell state transitions are decoupled from cell division during early ...
2024年11月8日 · We show that cell division is dispensable for differentiation of all embryonic tissues from early gastrulation to the end of segmentation. However, arresting cell division does slow down...
Single-cell analysis of bidirectional reprogramming between early ...
2 天之前 · A challenge in studying early mammalian embryos is their relatively small size, limited cell number, and availability. Stem cell models representing lineages of the embryo serve as in vitro alternatives, thus overcoming these limitations. Embryonic stem (ES) cells represent the pluripotent EPI, 9, 10 and extra-embryonic endoderm stem (XEN) cells represent the …
Global decoupling of cell differentiation from cell division in …
2023年7月29日 · We show that cell division is dispensable for differentiation of all embryonic tissues during initial cell type differentiation from early gastrulation to the end of segmentation. In the absence of cell division, differentiation slows down in some cell types, and cells exhibit global stress responses.
Maternal and embryonic signals cause functional differentiation …
Our findings provide insights into endometrial luminal epithelial cell development directed by maternal and embryonic signaling, which is crucial for endometrial receptivity. Successful embryo implantation requires precise interactions between a receptive endometrium and an activated blastocyst in mammals.
Integrating cellular dimensions with cell differentiation during …
In this review, we summarize recent advances that elucidate the contribution of the physical dimensions of a cell to major embryonic transitions and cell fate specification in vivo. We also highlight techniques and newly evolving methods for manipulating the sizes and shapes of cells and whole embryos in situ and ex vivo.