Influence of cholesterol on liposome stability and on in vitro drug ...
Cholesterol plays a strategic role in liposome composition; however, the quantity used to achieve an appropriate formulation has not been yet clarified. Therefore, by screening arrangement of lipids and cholesterol ratio, the main aim of this study is …
Cholesterol-mediated functionalization of liposomes for artificial …
2024年10月1日 · This review summarizes the various designs and applications of cholesterol-based anchors in liposomes, including surface macromolecular modification of liposomes to achieve improved properties and functionalization, cholesterol-mediated liposome membrane fusion, and cholesterol-mediated hierarchical construction of liposomes as artificial cell ...
Cholesterol modulates the liposome membrane fluidity and permeability ...
2018年3月1日 · The effect of cholesterol (CHOL) content on the permeability and fluidity of dipalmitoylphosphatidylcholine (DPPC) liposome membrane was investigated. Liposomes encapsulating sulforhodamine B (SRB), a fluorescent dye, were prepared by reverse phase evaporation technique (REV) at various DPPC:CHOL molar ratios (from 100:0 to 100:100).
Liposomes: structure, composition, types, and clinical applications ...
2022年5月1日 · Incorporation of cholesterol into liposomes is indispensable since cholesterol modulates membrane permeability, changes fluidity, and improves the stability of bilayer membranes in the presence of biological fluids such as blood and plasma [31, 32].
Cholesterol-modified sphingomyelin chimeric lipid bilayer for …
2024年3月7日 · Cholesterol (Chol) fortifies packing and reduces fluidity and permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery.
Liposomes: Structure, Biomedical Applications, and Stability …
Cholesterol has been shown to increase liposome stability through various mechanisms, including increased retention time, modulating phospholipid packing, Tm, and plasma stability. However, the optimal amount of cholesterol has not yet been identified.
Cholesterol Derivatives Based Charged Liposomes for Doxorubicin ...
2012年11月13日 · Cholesterol plays a critical role in liposome composition. It has great impact on the behavior of liposome in vitro and in vivo. In order to verify the possible effects from cholesterol charge, surface shielding and chemical nature, two catalogs of liposomes with charged and PEGylated cholesterols were synthesized.
The effect of cholesterol concentration on planar and spherical …
2024年2月8日 · In this study, coarse-grained molecular dynamics simulations are performed to characterize the effect of cholesterol concentration on planar and spherical lipid bilayers. To prepare liposomes, we simulate DOPC phospholipid combined with different molar ratios of cholesterol in both planar and spherical bilayers.
Liposome bilayer stability: emphasis on cholesterol and its ...
2023年6月28日 · This review aims to provide a perspective and a clear idea about the main factors that regulate the liposomes’ colloidal and bilayer stability, emphasising the roles of cholesterol and its possible alternatives.
A Reliable Quantification of Cholesterol and 25 ... - ACS Publications
2024年4月17日 · Study results showed that the method presents good specificity for cholesterol and 25-hydroxycholesterol detection in the liposomal matrix, good sensitivity characterized by LOD/LOQ in the nanomolar range, and accuracy within the range of 80 to 120%.