Conservation and turnover of miRNAs and their highly …
2021年2月24日 · Here, we assess the conservation of miRNAs and their targets by small RNA sequencing followed by miRNA target prediction in eight species of Anthozoa (sea anemones and corals), the earliest-branching cnidarian class. We uncover dozens of novel miRNAs but only a few conserved ones.
Conservation and evolution of miRNA regulatory programs in …
New genetic and biochemical studies of miRNA pathways in Arabidopsis, the spatiotemporal expression patterns of several conserved miRNAs and their targets, and the characterization of mutations in Arabidopsis and maize have begun to reveal the functions of these ancient miRNA-regulated developmental programs.
Conservation and divergence of plant microRNA genes
2006年3月30日 · All miRNAs have similar secondary hairpin structures; many of these are evolutionarily conserved. This suggests a powerful approach to predict the existence of new miRNA orthologs or homologs in other species. We developed a comprehensive strategy to identify new miRNA homologs by mining the repository of available ESTs.
Most mammalian mRNAs are conserved targets of microRNAs
In total, >45,000 miRNA target sites within human 3′UTRs are conserved above background levels, and >60% of human protein-coding genes have been under selective pressure to maintain pairing to miRNAs.
Conservation and evolution of miRNA regulatory programs in …
2007年10月1日 · Studies in Arabidopsis and maize have revealed a high level of conservation of developmental miRNA pathways between core eudicots and monocots. Lateral organ outgrowths are thought to arise by the juxtaposition of adaxial and abaxial polarities; in the absence of both fates, radialized organs are formed (reviewed in reference [ 66 ]).
Conservation and novelty in the microRNA genomic landscape of ...
2019年9月25日 · Our results show how conserved and evolutionarily novel miRNAs differ in their contribution to the genomic landscape and highlight their particular evolutionary roles in the adaptive...
Evolutionary conservation of microRNA regulatory programs …
2013年8月15日 · This review summarizes recent insights into the essential roles that miRNAs play in flower development. Nine highly conserved miRNA families have been implicated in regulating flower development. Most show considerable conservation among all most land plants at the levels of sequence conservation and target identities.
Inference of miRNA targets using evolutionary conservation and …
2007年3月1日 · We developed a general Bayesian method for the inference of miRNA target sites, in which, for each miRNA, we explicitly model the evolution of orthologous target sites in a set of related species. Using this method we predict target sites for all known miRNAs in flies, worms, fish, and mammals.
Clustering and conservation patterns of human microRNAs
MicroRNAs (miRNAs) are ∼22 nt-long non-coding RNA molecules, believed to play important roles in gene regulation. We present a comprehensive analysis of the conservation and clustering patterns of known miRNAs in human. We show that human miRNA gene ...
Clustering and conservation patterns of human microRNAs
2005年1月1日 · Here, we conduct a comprehensive analysis of the genomic organization and conservation patterns of miRNA genes in the human genome. We show that 37% of the known human miRNA genes included in this study are highly clustered and have typical conservation patterns, persistent along the cluster.