Contact inhibition - Wikipedia
Furthermore, recent studies have further revealed some mechanisms of contact inhibition of proliferation and its potential implications in cancer therapy. Furthermore, it has been shown that cell-cell adhesion formation not only restricts growth and proliferation by imposing physical constraints such as cell area, but also by triggering ...
Contact inhibition controls cell survival and proliferation ... - Nature
2018年7月27日 · Contact inhibition enables noncancerous cells to cease proliferation and growth when they contact each other. This characteristic is lost when cells undergo malignant...
E-cadherin in Contact Inhibition and Cancer - PMC - PubMed …
Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and …
Close Encounters of the Cell Kind: The Impact of Contact Inhibition on ...
An outstanding and important question concerns contact inhibition of proliferation (CIP), the observation that proliferation ceases when cells are spatially confined by their neighbours. CIP is a characteristic of many healthy adult tissues, but it remains unclear to which extent it holds in solid tumours, which exhibit regions of hyper ...
Contact Inhibition - an overview | ScienceDirect Topics
The loss of contact inhibition in both locomotion and proliferation is considered a hallmark of cancer, which involves defective adherens junction formation in part due to loss of E-cadherin in many malignant cells.
A revisited concept: Contact inhibition of growth. From cell …
2017年10月1日 · Contact inhibition is one of the key processes deregulated in transformed cells during carcinogenesis. The majority of cancer cells are refractory to the confluence-induced proliferation arrest [17] and loss of contact inhibition is actually used as an in vivo prognostic factor in human cancer [18].
E-cadherin in contact inhibition and cancer - PubMed
Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and …
Hypersensitivity to contact inhibition provides a clue to cancer ...
2009年11月11日 · Contact inhibition is a key anticancer mechanism that arrests cell division when cells reach a high density. In cell culture, naked mole-rat fibroblasts arrest at a much lower density than those from a mouse. We demonstrate that early contact inhibition requires the activity of p53 and pRb tumor suppressor pathways.
E-cadherin in contact inhibition and cancer | Oncogene - Nature
2018年5月21日 · Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of...
Contact inhibition and high cell density deactivate the ... - PNAS
2014年6月2日 · In cancer cells, lacking CI, mTOR was still inhibited in high cell density by an alternative mechanism. Our work explains why CI is reversible and how cells can avoid senescence in vivo, allowing the organism to last for decades. Implications for …
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