单细胞测序——髓系细胞注释marker - 简书
WEBMay 18, 2021 · M1和M2型注释：M1（FCGR3A）和M2（CD163）通常很难区分，一般会表达两种状态的marker gene。 文献中提供的注释方法是计算M1和M2极化和抗炎促炎分数，确定M1-like和M2-like的巨噬细胞。
Transcriptional Basis of Mouse and Human Dendritic Cell …
WEBOct 31, 2019 · To determine if counterparts of the newly characterized mouse cDC2 subsets exist in human blood we examined the correlation between gene expression characteristic of the identified mouse DC clusters and gene signatures of human DCs extracted from a recently published scRNA-seq analysis of human peripheral blood myeloid cells (PBMCs) (Villani et ...
Unraveling the Heterogeneity and Ontogeny of Dendritic Cells …
WEBSep 9, 2021 · In this review, we discuss recent landmark findings in DC classification and the lineages determined using scRNA-seq technologies. We focus on the applications of scRNA-seq in pathological states, particularly in the tumor environment. Finally, we describe the challenges and future trends of scRNA-seq technologies and DC research.
Frontiers | Unraveling the Heterogeneity and Ontogeny of …
WEBSep 8, 2021 · Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the understanding of DC subsets. In this review, we discuss in …
Dendritic cell subsets in cancer immunity and tumor antigen sensing
WEBMar 22, 2023 · TLR9, the first identified DNA-sensing receptor expressed in innate immune cells, is critical in mediating the accumulation, antigen uptake, lymph node migration, and maturation of tumor DCs...
Tumour-retained activated CCR7 + dendritic cells are ... - Nature
WEBJan 24, 2024 · Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme ...
Human dendritic cell subsets: An updated view of their ontogeny …
WEBMar 11, 2022 · Recent single‐cell RNA‐seq (scRNA‐seq) studies have also shown that all human DC subsets express a common activation program upon maturation, both homeostatic and induced by inflammatory stimuli .
Decoding the Heterogeneity of Human Dendritic Cell Subsets
WEBDec 1, 2020 · ScRNA-seq analyses of human DC subsets have revealed unexpected heterogeneity within cDC2 and pDC subsets, leading to the identification of new populations. AXL + SIGLEC6 + DCs display a mixed pDC/cDC transcriptional profile and can differentiate into cDC2 when placed in culture.
Unraveling the Heterogeneity and Ontogeny of Dendritic Cells …
WEBSep 9, 2021 · Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the understanding of DC subsets. In this review, we discuss in detail the remarkable perspectives in DC reclassification and ontogeny as revealed by scRNA-seq.
Machine-learning and combined analysis of single-cell and
WEBJul 28, 2023 · An unique signature based on DC marker genes that is highly predictive of LUAD patients’ prognosis and response to immunotherapy. CTSH is a new biomarker for LUAD. Innate immune effectors, dendritic cells (DCs), influence cancer prognosis and immunotherapy significantly.
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