Recent advances in electrocatalytic generation of indole-derived ...
2024年4月1日 · Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines.
Electrochemical oxidation of 3-substituted indoles - Organic ...
2023年6月22日 · Cyclic voltammetry and control studies infer that the reaction proceeds by electrochemical generation of elemental bromine (Br 2) that upon reaction with indole, followed by hydrolysis, delivers the 2-oxindole. This procedure is an appealing alternative to existing methods used to access 2-oxindoles by oxidation of the parent indole.
Scalable Electrochemical Aerobic Oxygenation of Indoles to …
2022年6月9日 · An approach to electrochemical oxygenation of indoles leading to isatins was developed by merging with a complementary cathode oxygen reduction reaction. The features of this green protocol include the use of molecular oxygen as the sole oxidant, it being free of an electron transfer mediator, and gram-scale preparation.
Electrochemical Dearomative 2,3-Difunctionalization of Indoles
2019年1月23日 · We report the use of electrochemistry to perform a direct oxidative dearomatization of indoles leading to 2,3-dialkoxy or 2,3-diazido indolines under undivided conditions at a constant current. This operationally simple electro-oxidative procedure avoids the use of an external oxidant and displays excellent functional group compatibility.
Electrochemical Skeletal Indole Editing via Nitrogen Atom …
2024年7月3日 · Herein, we report the electrochemical nitrogen atom insertion reaction into indoles enabled by the oxygen reduction reaction (ORR). Thus, leading to the formation of biologically active quinazoline scaffolds. Skeletal molecular editing gained considerable recent momentum and emerged as a uniquely powerful tool for late-stage diversifications.
One-electron oxidation of indoles and acid-base properties of …
The reaction of oxygen with radicals from oxidation of tryptophan and indole-3-acetic acid. Biophysical Chemistry 1997, 67 (1-3) , 229-237. https://doi.org/10.1016/S0301-4622(97)00052-5
Electrochemical and peroxidase O2-mediated oxidation of indole-3 …
1997年7月30日 · In this investigation the electrochemically driven and peroxidase/O 2 -mediated oxidation chemistry of IAA at physiological pH has been studied with the primary goal of identifying the major reaction products.
Recent advances in the oxidative activation of the C2–C3 π bond …
2024年12月4日 · The oxidative C2–C3 π bond activation strategy is the most efficient tool to synthesize oxygen-containing indoline, which frequently appears in natural products with various biological activities as structural units. Recently, the oxidation-induced cascade strategy through oxygenation activation of the indolic C2–C
A new organic redox species-indole tetraone trapped MWCNT …
2018年4月1日 · Herein, we report an electrochemical oxidation of electro-inactive indole to a multi-redox active indole-tretraone (1H-Indole-2,3,4,7-Tetraone; Ind-Tetraone) and entrapment as a surface-confined redox active species on multiwalled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE/MWCNT@Ind-Tetraone)in physiological pH solution.
Electrooxidation enables highly regioselective dearomative annulation ...
2020年1月7日 · The plausible mechanism involves anodic oxidation of indole to generate indole radical cation. Two steps of nucleophilic attack by ethylene glycol accompanied with an oxidation process would ...