RNA splicing - Wikipedia
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre- mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns (non-coding regions of RNA) and …
RNA Splicing | Learn Science at Scitable - Nature
One of the steps in this processing, called RNA splicing, involves the removal or "splicing out" of certain sequences referred to as intervening sequences, or introns. The final mRNA thus...
Exonic splicing enhancer - Wikipedia
In molecular biology, an exonic splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous nuclear RNA or pre-mRNA into messenger RNA .
RNA剪接 - 維基百科，自由的百科全書
自剪接 （ 英語 ： self-splicing ） 出現在稀少的內含子組成核酸酶，核酸酶在只有RNA的情況下代替了剪接體的功能。自剪接的內含子有三種，稱為第一型、第二型及第三型。
A unified mechanism for intron and exon definition and back-splicing
The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryoEM structures of the yeast E complex assembled on introns, providing the first view of the earliest event in the splicing cycle that commits pre-mRNAs to splicing.
Splicing complexity as a pivotal feature of alternative exons in ...
2023年4月12日 · By comparing splicing complexity of exons in six tissues (brain, cerebellum, heart, liver, kidney, and testis) from six mammalian species (human, chimpanzee, gorilla, macaque, mouse, opossum) and an outgroup species (chicken), we revealed that exons with high splicing complexity are prevalent in mammals and are closely related to features of genes.
Alternative splicing and evolution: diversification, exon definition ...
2010年4月8日 · There are three known evolutionary mechanisms that could account for the appearance of an alternatively spliced exon: exon shuffling (a form of gene duplication), exonization of intronic...
Exon- Definition, Structure, Splicing, Process of Splicing
2022年4月9日 · Exons are interspaced by introns in a gene. The process of splicing (a post-transcriptional process) removes the introns (non-coding regions) and joins the exons. Nucleotide sequences in DNA or RNA which are expressed are known as exons. Exons are conserved in DNA or mature RNA. Exon structure includes the untranslated regions from both 5` and 3`.
RNA exon editing: Splicing the way to treat human diseases
RNA exon editing is a therapeutic strategy for correcting disease-causing mutations by inducing trans -splicing between a synthetic RNA molecule and an endogenous pre-mRNA target, resulting in functionally restored mRNA and protein.
A unified mechanism for intron and exon definition and back-splicing …
2019年9月4日 · The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast...