FcγR Binding and ADCC Activity of Human IgG Allotypes
网页2020年5月6日 · Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and …
The Role of Fc Receptors on the Effectiveness of Therapeutic …
网页2021年8月19日 · ADCC and ADCP are two mechanisms mediated by direct interaction of the antibody’s Fc domain with the corresponding FcγR. ADCC is mainly attributed to NK cells, but also neutrophils and eosinophils, which exert their cytotoxic activities upon activation by the activating FcγRIIIa.
Fcγ receptors as regulators of immune responses - Nature
网页Important examples for effector responses that are regulated by FcγRs are phagocytosis, ADCC and the release of inflammatory mediators. On dendritic cells (DCs), paired FcγR expression...
FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint ...
网页2019年2月26日 · Fc endows IgG antibodies with effector functions, which include antibody dependent-cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), Induction of cytokines/chemokines and endocytosis of opsonized targets .
Mechanisms and targets of Fcγ-receptor mediated immunity to ... - Nature
网页2021年3月19日 · In addition to phagocytosis, neutrophils and natural killer (NK) cells can also kill cells through antibody-dependent cellular cytotoxicity (ADCC) 23,24, and both monocytes and neutrophils also...
A new mouse expressing human Fcγ receptors to better predict ...
网页2017年9月19日 · FcγR engagement has been shown to be the critical determinant of mAb therapeutic efficacy in humans. 1, 2 An antibody’s Fc domain’s relative affinity for the activating and inhibitory FcγR,...
FcγR: The key to optimize therapeutic antibodies? - ScienceDirect
网页2007年4月1日 · Activating FcγR induce antibody-dependent cell cytotoxicity (ADCC), endocytosis of immune complexes followed by antigen presentation, phagocytosis, and release of cytokines or pro-inflammatory mediators.
Frontiers | Fc Gamma Receptors and Their Role in Antigen Uptake ...
网页2020年7月2日 · Depending on the cell type and context, FcγRI, FcγRIIA, and FcγRIIIA aggregation can lead to degranulation, phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), but also cytokine production and secretion of inflammatory mediators. Some of these activating FcγR mediated effects will be discussed later in this article.
FcγR Binding and ADCC Activity of Human IgG Allotypes
网页2020年5月6日 · Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and …
Activating FcγR function depends on endosomal-signaling platforms
网页Destabilization of FcγR endosomal signaling in the absence of IRAP compromised cytokine secretion downstream FcγR activation and macrophage ability to kill tumor cells by antibody-dependent cell-mediated cytotoxicity (ADCC). Our results indicate that FcγR endosomal signaling is required for the FcγR-driven inflammatory reaction and possibly ...