Tissue-resident FOLR2+ macrophages associate with CD8+ T cell …
网页2022年3月31日 · The density of FOLR2 + macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.
Three tissue resident macrophage subsets coexist across organs …
网页2022年1月7日 · They defined three recurring transcriptionally related macrophage subsets with unique core gene signatures, which can be stratified based on expression of TIMD4, LYVE1, FOLR2, CCR2, and MHC-II.
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell ...
网页2022年3月23日 · We identify two phenotypically distinct macrophage populations: (1) TREM2 + macrophages expressing triggering receptor expressed by myeloid cells-2 (TREM2) and osteopontin (SPP1) genes, (2) FOLR2 + macrophages expressing folate receptor 2 (FOLR2), hyaluronan receptor (LYVE-1), and mannose receptor C-Type 1 (MRC1/CD206) genes.
Single-cell profiling reveals the trajectory of FOLR2 ... - Nature
网页2023年8月2日 · Buggattie and colleagues presented two distinct macrophage subsets co-expressed with FOLR2 and TIM4, which may have opposing roles in tumorigenesis and tumor immunity across several cancer...
WNT-dependent interaction between inflammatory fibroblasts and FOLR2 …
网页2024年1月25日 · We demonstrate that CXCL-iFibro co-localize with macrophages in the kidney and participate in their attraction, accumulation, and switch into FOLR2+ macrophages from early CKD stages on.
网页The enrichment of TAM-FOLR2 in IA might result from alveolar resident macrophage-resistin (ARM-RETN) transformation and recruitment of dendritic cells (DCs) and other TAMs, as evidenced by
FOLR2 + Macrophages Are Associated with T-cell Infiltration and ...
网页2022年6月2日 · Major Finding: FOLR2 + macrophages are associated with improved survival in patients with breast cancer. Concept: These tissue-resident macrophages interact with CD8 + T cells and are correlated with their infiltration. Impact: These findings suggest subtype-focused therapeutic interventions against macrophages in cancer.
Frontiers | Understanding tissue-resident macrophages unlocks …
网页2024年6月14日 · A study in B6 green fluorescent protein (GFP)-transgenic mice with TNBC shows that FOLR2 + tissue-resident macrophages dominate the TME (42%–49%), and treatment with clodronate liposomes (which induces apoptosis in macrophages) in a local recurrence model prevented lung and liver metastasis in TNBC .
Single-cell profiling reveals the trajectory of FOLR2 ... - PubMed
网页2023年8月3日 · The enrichment of TAM-FOLR2 in IA might result from alveolar resident macrophage-resistin (ARM-RETN) transformation and recruitment of dendritic cells (DCs) and other TAMs, as evidenced by temporal trajectories and differential expression profiles of chemokine ligands/receptors versus those in the early stages of tumors.
Single-cell profiling reveals the trajectory of FOLR2-expressing …
网页2023年8月2日 · Myeloid cells and T cells were the most abundant cell types in tumors and normal lung tissues, while tumor-associated macrophage-folate receptor 2 (TAM-FOLR2) and CD4 + nuclear receptor subfamily 4 group A member 3 (NR4A3) exhibited sharp increases in invasive adenocarcinoma (IA).