Glycans and cancer: role of N-glycans in cancer biomarker ... - PubMed
This review focuses on glycan structures, their biosynthetic glycosyltransferases, and their genes in relation to their biological significance and involvement in cancer, especially cancer biomarkers, epithelial-mesenchymal transition, cancer …
Targeting Tumor Glycans for Cancer Therapy: Successes, …
2022年1月27日 · Glycans can serve as a source of novel clinical biomarker developments, providing a set of specific targets for therapeutic intervention. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs) suitable for selective cancer-targeting therapy.
Glycosylation Changes in Cancer - Essentials of Glycobiology
Altered glycosylation is a universal feature of cancer cells, and certain glycans are well-known markers of tumor progression. This chapter discusses glycan biosynthetic pathways that are altered in cancer cells; correlations between altered glycosylation, diagnosis, and clinical prognosis; the genetic bases of some of these changes; and the ...
Altered glycosylation in cancer: A promising target for biomarkers …
The ability of glycans in intervening various stages of tumor progression and the biosynthetic pathways involved in glycan structures constitute a promising target for cancer therapy. Advances in the knowledge of innovative strategies for identifying the mechanisms of glycan-binding proteins are hoped to hold great potential in cancer therapy.
Glycosylation in cancer: mechanisms and clinical implications
2015年8月20日 · Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell–matrix...
Altered glycosylation in cancer: A promising target for ... - PubMed
This review discusses the fundamental role of glycans in regulating tumorigenesis and tumor progression and provides insights into the influence of glycans in the current tactics of targeted therapies in the clinical setting.
Glycoproteomics-based signatures for tumor subtyping and …
2020年12月1日 · To investigate the roles of protein glycosylation in the heterogeneity of high-grade serous ovarian carcinoma (HGSC), we perform mass spectrometry-based glycoproteomic characterization of 119 TCGA...
Glycosylation in the Era of Cancer-Targeted Therapy: Where Are …
2019年7月8日 · The roles of glycosylation in cancer signaling, tumor progression, and metastasis are reviewed as well as glycans and glycan-binding proteins in tumor immunomodulation. Moreover, the latest reports on glycans influencing targeted therapeutic approaches in cancer are summarized.
Targeting Tumor Glycans for Cancer Therapy: Successes ... - MDPI
2022年1月27日 · Glycans can serve as a source of novel clinical biomarker developments, providing a set of specific targets for therapeutic intervention. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs) suitable for selective cancer-targeting therapy.
Metabolic glycan labelling for cancer-targeted therapy
2020年11月20日 · Unnatural sugar-mediated metabolic labelling of cancer cells has demonstrated the ability to remodel cell-surface glycans, regulate the function of cell-surface receptors and downstream...