Mitochondrial depolarization following hydrogen sulfide exposure …
In erythrocytes exposed to 0.11-1.9 mmol l-1 sulfide for 1 h, the dyes showed fluorescence changes consistent with sulfide-induced mitochondrial depolarization. At the highest sulfide concentration, the extent of depolarization was equivalent to that caused by the mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP).
Depolarizing Actions of Hydrogen Sulfide on Hypothalamic ...
2013年5月17日 · Hydrogen sulfide (H 2 S) is a novel neurotransmitter that has been shown to influence cardiovascular functions as well and corticotrophin hormone (CRH) secretion. Since the paraventricular nucleus of the hypothalamus (PVN) is a central relay center for autonomic and endocrine functions, we sought to investigate the effects of H 2 S on the ...
Mitochondrial depolarization following hydrogen sulfide exposure …
2005年11月1日 · In erythrocytes exposed to 0.11-1.9 mmol l -1 sulfide for 1 h, the dyes showed fluorescence changes consistent with sulfide-induced mitochondrial depolarization. At the highest sulfide concentration, the extent of depolarization was equivalent to that caused by the mitochondrial uncoupler carbonyl cyanide m -chlorophenylhydrazone (CCCP).
Hydrogen Sulfide Induces Oxidative Damage to RNA and DNA in a Sulfide …
To investigate whether sulfide has the potential for lasting, sublethal toxicity in a sulfide-tolerant organism, we tested the hypothesis that a broad range of sulfide concentrations induces evidence of dose-dependent, oxygen-centered free radical production and causes oxidative damage to RNA and DNA in the sulfide-tolerant polychaete Glycera ...
Hydrogen sulfide depolarizes neurons in the nucleus of the …
2016年2月15日 · We report of direct H 2 S effects on membrane potential of NTS neurons. H 2 S has reversible, depolarizing effects on 95% of NTS neurons tested (72/76). These effects were postsynaptic (observed in tetrodotoxin and kynurenic acid). Depolarization was followed by a hyperpolarization in 64% of neurons.
Depolarizing actions of hydrogen sulfide on hypothalamic ...
2013年5月17日 · Input differences from baseline and during the NaHS-induced depolarization uncovered a biphasic response, implicating both a potassium and non-selective cation conductance. The results from the neuronal population of the PVN shed light on the possible physiological role that H2S has in autonomic and endocrine function.
Depolarizing Actions of Hydrogen Sulfide on Hypothalamic ...
2013年5月17日 · Input differences from baseline and during the NaHS-induced depolarization uncovered a biphasic response, implicating both a potassium and non-selective cation conductance. The results from the...
H 2 S remodels mitochondrial ultrastructure and destabilizes ...
2024年10月30日 · Sulfide-dependent depolarization of the inner mitochondrial membrane is associated with loss of cristae and respiratory supercomplexes. Our study reveals the potential for sulfide to be an endogenous regulator of mitochondrial ultrastructure and function via modulation of electron flux and for this process to be corrupted in sulfide ...
Depolarizing Actions of Hydrogen Sulfide on Hypothalamic
2013年5月17日 · Hydrogen sulfide-induced depolarization is mediated by multiple ion channels. In order to identify potential ion channels responsible for the NaHS-induced depolarization, we applied hyperpolarizing current step protocols to the neurons to …
The mitochondrial NADH pool is involved in hydrogen sulfide …
2021年4月7日 · Hydrogen sulfide is synthesized by enzymes involved in sulfur metabolism and oxidized via a dedicated mitochondrial pathway that intersects with the electron transport chain at the level of complex III. Studies with H2S are challenging since it is volatile and also reacts with oxidized thiols in the culture medium, forming sulfane sulfur species.