Insulator (genetics) - Wikipedia
The genetic implications of insulators lie in their involvement in a mechanism of imprinting and their ability to regulate transcription. Mutations to insulators are linked to cancer as a result of cell cycle disregulation, tumourigenesis, and silencing of growth suppressors.
Insulators: exploiting transcriptional and epigenetic mechanisms
2006年8月15日 · Insulators are DNA sequence elements that help to prevent inappropriate interactions between adjacent regions of the genome. There are two types of insulator — one that is involved in...
绝缘子 (基因) - 维基百科，自由的百科全书
绝缘子（英語： insulator ）是真核生物 基因组的调控元件之一，亦为一种边界元件。 功能为阻止临近调控元件，对它所界定基因的 启动子 起增强或者阻遏的作用。
The Functions and Mechanisms of Action of Insulators in the …
THE ROLE PLAYED BY INSULATORS AND TADS IN TRANSCRIPTION REGULATION. Drosophila insulators play a significant role in ensuring specific long-range cis-regulatory interactions, which has been demonstrated well for the BX-C .
Insulators are fundamental components of the eukaryotic …
2005年4月6日 · Insulators are regulatory elements that can shelter genes from inappropriate regulatory interactions. Transgenic assays have helped to dissect the exact sequences required for insulation and have...
Chromatin Insulators: Regulatory Mechanisms and Epigenetic …
2008年10月10日 · Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are many regulatory mechanisms in place that enhance or hinder insulator activity.
Insulators: many functions, many mechanisms - Genes
Insulator proteins constitutively recruit histone acetyltransferases that acetylate flanking nucleosomes (red spheres). Acetylation serves to inhibit histone modifications required for the propagation of transcriptionally silent condensed chromatin (packed blue spheres).
Genomic insulators: connecting properties to mechanism
2003年6月1日 · Insulators are regulatory elements that establish independent domains of transcriptional activity within eukaryotic genomes. Insulators possess two properties: an anti-enhancer activity that blocks enhancer–promoter communication, and an anti-silencer activity that prevents the spread of repressive chromatin.
Insulators and promoters: closer than we think - Nature
2010年5月5日 · Insulators prevent promiscuous gene regulation by restricting the action of enhancers and silencers. Recent studies have revealed a number of similarities between insulators and promoters,...
Transcriptional control: The benefits of selective insulation - Cell …
2000年3月15日 · In eukaryotes, cis-regulatory sequences are often a long way away from the transcription start site, and interactions between regulatory elements can be blocked by ‘insulator’ sequences. A novel type of cis-regulatory element has now been found that selectively permits some interactions across insulators.