Juno is the egg Izumo receptor and is essential for mammalian
2014年4月16日 · The egg receptor for Izumo, a sperm cell-surface protein required for male fertility, is identified here and renamed Juno; these findings show that the Izumo–Juno interaction is conserved...
Structure of IZUMO1–JUNO reveals sperm–oocyte recognition …
2016年6月15日 · The structure of the IZUMO1–JUNO complex, crucial for sperm–oocyte interaction during fertilization, is reported, providing a first step towards understanding the mechanics of the interaction.
Molecular dynamics of JUNO-IZUMO1 complexation suggests
2023年11月20日 · JUNO-IZUMO1 binding is the first known physical link created between the sperm and egg membranes in fertilization, however, how this initiates sperm-egg fusion remains elusive.
Structural and functional insights into IZUMO1 recognition by JUNO …
2016年7月15日 · Sperm–egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and JUNO (also known as folate receptor (FR) 4 or IZUMO1R) on the egg surface. Whereas other FRs bind and uptake folates, JUNO binds IZUMO1 and establishes the cell–cell adhesion.
JUNO, the receptor of sperm IZUMO1, is expressed by the human …
2018年12月5日 · Our data showing that anti-hJUNO mAbs completely block human fertilisation in vitro, together with (i) the presence of IZUMO1 on the head of acrosome reacted-human sperm (Inoue et al., 2005), (ii) the inhibition of human sperm fusion with hamster oocytes in the xeno-species fusion system induced by the anti-human IZUMO1 polyclonal antibody ...
Izumo1 and Juno: the evolutionary origins and coevolution of …
2015年12月16日 · Izumo1 is the only essential sperm–egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm–egg binding proteins are shown to be evolving under positive selection.
Izumo meets Juno - PMC - National Center for Biotechnology …
2014年7月1日 · Izumo (red) is displayed on the surface of acrosome-reacted sperm and interacts with Juno (green) on the surface of ovulated eggs. Following fertilization, Juno is rapidly shed from the egg membrane and redistributed as vesicles, which may bind and rapidly neutralize subsequent incoming acrosome-reacted sperm, thereby reducing the possibility ...
Molecular architecture of the human sperm IZUMO1 and egg JUNO ...
2016年6月23日 · The human IZUMO1 structure exhibits a distinct boomerang shape and provides structural insights into the IZUMO family of proteins. Human IZUMO1 forms a high-affinity complex with JUNO and undergoes a major conformational change within its N-terminal domain upon binding to the egg-surface receptor.
(PDF) Izumo1 and Juno: The evolutionary origins and coevolution …
2015年12月18日 · Izumo1 is the only essential sperm–egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and...
(PDF) Molecular dynamics of JUNO-IZUMO1 complexation …
2023年11月20日 · PDF | JUNO-IZUMO1 binding is the first known physical link created between the sperm and egg membranes in fertilization, however, how this initiates... | Find, read and cite all the research you...