KEGG PATHWAY: Biotin metabolism - Homo sapiens (human)
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways.
A bacterial methyltransferase that initiates biotin synthesis, an ...
2024年12月20日 · We report the functional definition of two BioC isoenzymes (AbBioC for A. baumannii and KpBioC for K. pneumoniae) that act as malonyl-ACP methyltransferase and initiate biotin synthesis. The physiological requirement of biotin is diverse within ESKAPE pathogens.
KAAS - KEGG Automatic Annotation Server - GenomeNet
KAAS (KEGG Automatic Annotation Server) provides functional annotation of genes by BLAST or GHOST comparisons against the manually curated KEGG GENES database. The result contains KO (KEGG Orthology) assignments and automatically generated KEGG pathways. KAAS works best when a complete set of genes in a genome is known.
kegg-kass注释--转载 - CSDN博客
2016年12月29日 · 化学分子物质数据库，以及基于基因和化学分子物质相互关系而建立起来的代谢路径数据库，在KEGG数据库中，有一个“专有名词”KO（KEGG Orthology），它是蛋白质（酶）的一个分类体系，序列高度相似，并且在同一条通路上有相似功能的蛋白质被归为一组，然后打上KO（或K标签，KEGG orthology (ko)代表的是某个代谢途径，k代表的是某个酶，c代表的是某个化合物，M代表的是某个模块，后面都会跟着编号。 图中的正方形代表酶，圆形代表代谢 …
Biotin, a universal and essential cofactor: synthesis, ligation and ...
2021年1月11日 · Biotin is a covalently attached enzyme cofactor required for intermediary metabolism in all three domains of life. Several important human pathogens (e.g. Mycobacterium tuberculosis) require biotin synthesis for pathogenesis. Humans lack a biotin synthetic pathway hence bacterial biotin synthesis is a prime target for new therapeutic agents.
Closing in on complete pathways of biotin biosynthesis
Although the catalytic and physiological roles of biotin have been well characterized, the biosynthesis of biotin remains to be fully elucidated. Studies in microbes suggest a two-stage biosynthetic pathway in which a pimelate moiety is synthesized and used to begin assembly of the biotin bicyclic ring structure.
KEGG PATHWAY: Biotin metabolism
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways.
KAAS: an automatic genome annotation and pathway reconstruction server ...
Here, we have developed a web-based server called KAAS (KEGG Automatic Annotation Server: http://www.genome.jp/kegg/kaas/) i.e. an implementation of a rapid method to automatically assign K numbers to genes in the genome, enabling reconstruction of KEGG pathways and BRITE hierarchies.
PATHWAY: map00780 - KEGG
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways.
A bacterial methyltransferase that initiates biotin synthesis, an ...
We report the functional definition of two BioC isoenzymes (AbBioC for A. baumannii and KpBioC for K. pneumoniae ) that act as malonyl-ACP methyltransferase and initiate biotin synthesis. The physiological requirement of biotin is diverse within ESKAPE pathogens.
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