The role of leucine and its metabolites in protein and energy metabolism
Leu increases protein synthesis through activation of the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle, adipose tissue and placental cells. Leu promotes energy metabolism (glucose uptake, mitochondrial biogenesis, and fatty acid oxidation) to provide energy for protein synthesis, while inhibiting protein degradation.
Glucose-dependent control of leucine metabolism by leucyl …
2019年11月28日 · We propose that LARS1 mediates defense under glucose starvation by rebalancing leucine metabolism. Upon sensing leucine in the presence of glucose, LARS1 supports translation by leucylating tRNA and by activating mTORC1.
Branched Chain Amino Acids: Beyond Nutrition Metabolism
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals.
Leucine Metabolism | Encyclopedia MDPI
2020年10月29日 · Leucine metabolism plays key roles in anti-obesity effects on glucose tolerance, lipid metabolism, and insulin sensitivity, participating in diverse physiological and pathological processes.
Inhibition of BCAT1-mediated cytosolic leucine metabolism …
2024年8月1日 · Activated CD4 + T cells induce an alternative pathway of cytosolic leucine catabolism, generating a pivotal metabolite, β-hydroxy β-methylbutyric acid (HMB), by acting on BCAT1 and...
Leu increases protein synthesis through activation of the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle, adipose tis-sue and placental cells. Leu promotes energy metabolism (glucose uptake, mitochondrial biogenesis, and fatty acid oxidation) to provide energy for protein synthesis, while inhibiting protein degradation.
Potential role of leucine metabolism in the leucine-signaling pathway …
Leucine has been shown to stimulate adipose tissue protein synthesis in vivo as well as leptin secretion, protein synthesis, hyper-plastic growth, and tissue morphogenesis in in vitro experiments using freshly isolated adipocytes.
The role of leucine in the activation of cellular metabolism: a …
2022年11月23日 · Mammals adjusted the cell activation and growth rate of their young by the leucine concentration of the milk produced. Several studies demonstrate the benefits of leucine supplementation in preventing sarcopenia, improving muscle and liver performance, as well as a possible neuroprotective role in head trauma and dementia.
Modeling leucine's metabolic pathway and knockout prediction …
2015年7月14日 · The branched chain amino acids, i.e. leucine, valine, and isoleucine are produced by a metabolic pathway with complex regulatory mechanisms. The question is how to adapt this pathway of B. subtilis by gene knockouts, in order to overproduce leucine.
Reviewing the Effects of l-Leucine Supplementation in the …
Because leucine regulates several cellular processes via mTOR and possibly through other signaling pathways, the likely beneficial effects of leucine supplementation have been evaluated in a variety of situations, including as a dietary supplement for the treatment of obesity and diabetes mellitus.
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