Human Insulin Analog–Induced Lipoatrophy - Diabetes Care
2008年3月1日 · OBJECTIVE—To characterize the pathophysiology of recombinant human insulin-induced lipoatrophy. RESEARCH DESIGN AND METHODS—We performed immunologic laboratory evaluation and skin testing for different insulin analogs and diluents in patients with type 1 diabetes and severe insulin-induced local lipoatrophy. Subcutaneous adipose tissue ...
View of Insulin induced lipodystrophy | British Journal of Diabetes
Insulin induced lipoatrophy and, more commonly, lipohypertrophy are dermatological complications of insulin therapy. Lipoatrophy is becoming less common with the advent of newer insulin analogues; however, lipohypertrophy is still prevalent.
Insulin lipodystrophy and lipohypertrophy - PMC - PubMed …
Insulin lipohypertrophy denotes to a benign tumor like swelling of fatty tissue at the injection site secondary to lipogenic effect of insulin, whereas lipoatrophy is considered an adverse immunological side effect of insulin therapy.
Human Insulin–Induced Lipoatrophy - Diabetes Care
2006年4月1日 · With the arrival of human insulin, lipoatrophy has decreased dramatically, becoming a rare problem in clinical practice. Lipoatrophies are considered an adverse immunological side effect of insulin therapy, and in some cases they are mediated by a local high production of tumor necrosis factor-α, which leads to a dedifferentiation of ...
Insulin-Induced Distant Site Lipoatrophy - Diabetes Care
2017年4月10日 · Computed tomography showed lipoatrophy of the right submandibular region, right anterior abdomen, and left buttock sites (Fig. 1D and E). Laboratory data showed high values of HbA 1c (8.9% [73 mmol/mol]) and fasting insulin levels (1,163 µU/mL). The insulin antibody titer was over 5,000 nU/mL, and the binding rate was 86.7%.
Lipohypertrophy and Insulin: An Update From the Diabetes …
2023年8月9日 · Lipohypertrophy is a common skin complication associated with insulin-treated diabetes. The impact of lipohypertrophy as a contributing factor to suboptimal glycemic control, glucose variability, and hypoglycemia is often under-recognized by health care professionals.
Insulin induced lipodystrophy | British Journal of Diabetes
2014年11月24日 · Insulin induced lipoatrophy and, more commonly, lipohypertrophy are dermatological complications of insulin therapy. Lipoatrophy is becoming less common with the advent of newer insulin analogues; however, lipohypertrophy is still prevalent.
Lipoatrophy Induced by Subcutaneous Insulin Infusion: …
2010年7月1日 · Lipoatrophy (LA), defined as a loss of sc fat around the site of repeated insulin injections, is a rare complication of insulin therapy causing erratic insulin absorption . In the past, 25–55% of insulin-treated patients displayed LA, probably due to a local allergic reaction to impurities present in insulin preparations ( 2 ).
Lipoatrophy, a rare complication of diabetes: a single-center ...
Background: Lipoatrophy (LA), a rare skin complication in patients with type 1 diabetes (T1D), has decreased dramatically over the past decades due to the use of human purified insulin preparations. Methods: We collected data from the records of T1D patients with LA.
Insulin-Related Lipohypertrophy: Lipogenic Action or Tissue …
2018年10月30日 · Repeated subcutaneous administration of insulin in the smaller area mount up the local lipogenic effect of insulin and injection-related tissue trauma, consequently, ensues lipohypertrophy in form of fatty lumps underneath the skin of that area .