Gut microbiota drives macrophage-dependent self-renewal of …
2022年4月4日 · The link between gut microbiota and intestinal epithelium homeostasis is a fascinating field, and increasing studies reveal “microbiota–epithelium” crosstalks such as “fungal metabolite ...
Polyphenol-rich diet mediates interplay between macrophage
2023年10月9日 · Dietary phenolic acids alleviate intestinal inflammation through altering gut microbiota composition and regulating macrophage activation. However, it is unclear how individual...
Crosstalk between gut microbiota and gut resident macrophages …
Macrophages residing in the gut maintain gut homeostasis by orchestrating patho-gens and innocuous antigens. A disturbance in macrophages leads to gut inflamma-tion, causing conditions such as inflammatory bowel disease (IBD). Macrophages ex-hibit remarkable plasticity, as they are sensitive to various signals in the tissue micro-environment.
Pregnancy-induced changes to the gut microbiota drive macrophage …
2023年2月14日 · The disturbance in gut microbiota induced by pregnancy increases susceptibility to sepsis by favoring macrophage pyroptosis due to the nucleus accumulation of hnRNPUL2, shedding light on potential therapies to limit sepsis severity.
Gut microbiota drives macrophage-dependent self-renewal of …
The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter. 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2 + macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes ...
Gut microbiota promotes stem cell differentiation through macrophage …
2022年12月13日 · Here, we show that gut microbiota exposure promotes macrophage differentiation, which maintains MNC proliferation and subsequently activates epithelial Wnt signaling required for stem cell differentiation in the early postnatal period, whereas perturbation of this process can lead to life-threatening NEC (Figure 7 G).
Intestinal macrophages and response to microbial encroachment
2010年10月20日 · Thus, in noninflamed mucosa, resident macrophages are inflammation anergic but retain avid scavenger and host defense function, an ideal profile for macrophages in close proximity to gut...
Microbiota regulates the turnover kinetics of gut macrophages …
2021年11月2日 · Maintenance of the gut lamina propria–resident macrophage cell pool requires monocyte input during adulthood. Here, Ruedl and colleagues demonstrate that the intestinal microbiome positively influences the replenishment of tissue-resident macrophages under both steady-state and inflammatory conditions.
A Special Network Comprised of Macrophages, Epithelial Cells, and Gut …
2022年1月17日 · Multiple specialized immune cell populations, such as macrophages, dendritic cells (DCs), innate lymphoid cells, and T regulatory (Treg) cells, can communicate with intestinal epithelial cells (IEC) and/or the gut microbiota bi-directionally. The gut microbiota contributes to the differentiation and function of resident macrophages.
Gut Microbiota, Macrophages and Diet: An Intriguing New …
Gut microbiota and diet are two key factors capable of modifying intestinal macrophage profiles, shaping their specific function. Defects in macrophage polarisation, inadequate dietary habits, and alteration of microbiota composition may contribute to the development of intestinal fibrosis.